Staff Scientist
Antibody Conjugation
Posted on 9/14/2023
Nautilus Biotechnology

51-200 employees

Advancing proteomics for improved drug development and diagnostics
Company Overview
Nautilus Biotechnology offers a unique, multidisciplinary approach to proteomics, leveraging the expertise of a diverse team of professionals ranging from protein chemists to software engineers. Their focus on developing a solution that combines sensitivity, dynamic range, and ease of use aims to make proteomics accessible to all researchers, potentially transforming drug development and medical diagnostics. This commitment to addressing complex challenges and advancing human health management positions Nautilus as a leader in their industry.
Data & Analytics

Company Stage


Total Funding





San Carlos, California

Growth & Insights

6 month growth


1 year growth


2 year growth

San Carlos, CA, USA
Experience Level
Desired Skills
Biology & Biotech
  • PhD plus 4-6+ years of industry experience or BS/MS plus 8-10+ years of industry experience
  • Deep experience with chemistry, especially as applied to orthogonal bioconjugation chemistry, chromatography and analytical techniques including HPLC, MS, LC/MS, and NMR
  • Experience in the synthesis and evaluation of reagents for use in antibody, protein, or peptide conjugates, including understanding of how modifications may impact function
  • Hands-on experience with multiple methods of bioconjugation
  • Hands-on experience with different purification methods and be able to characterize conjugates. Experience with complex affinity reagents preferred (polymeric compounds, nanoparticles, etc. Ability to effectively multitask and work in a fast-pace, goal-oriented environment
  • Ability to formulate, establish, and teach bioconjugation solutions
  • Highly organized with exquisite attention to detail
  • Self-motivated, driving projects forward to meet deadlines
  • Willingness to work collaboratively within a team as well as independently
  • Excellent written and oral communication skills
  • Agile-like approach to development
  • Invent, develop and optimize methods to build novel conjugates that combine bright fluorescent labels with Nautilus' antibodies and aptamers, collectively called probes, into high-affinity detection reagents
  • Work extensively with our Reagents R&D, Protein Discovery, and Formulations teams to implement strategies that enable site-specific conjugation and optimal presentation of the attached probes
  • Design methods for conjugating standard recombinant antibodies to create high-affinity detection reagents
  • Contribute to the design of experiments cross-functionally to evaluate the performance of conjugates on the Nautilus platform
  • In collaboration with the larger Applications team, meet with customers to understand the scientific questions they are seeking answers for and present bioconjugation solutions that Nautilus will utilize to push their projects forward
  • Work with our Sample Preparation and Reagents teams to design novel chemical linkers, moieties, and functional groups for conjugates with improved properties
  • Plan and evaluate synthetic routes for compounds of interest, if needed
  • Synthesize and/or work with synthesis CROs to bring new chemistries and compounds in-house, if needed
  • Design and carry out assays for both analytical and functional QC of small molecule compounds, conjugates, and complex reagents
  • Collaborate with our Formulation and Production teams to refine and transfer protocols