Computational Chemist I
Posted on 3/31/2023
INACTIVE
Locations
Dorchester, Boston, MA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Desired Skills
PowerPoint/Keynote/Slides
Requirements
  • Roll up your sleeves as an Individual Contributor (IC) and play an important role in our mission to use AI/ML to develop drugs against historically difficult disease targets
  • Ph.D. in chemistry
  • 2+ years of postdoctoral or industrial experience
  • Proficiency with the Microsoft Office Suite (Excel, Word, PowerPoint, Teams), G-Suite
Responsibilities
  • Computational chemistry programs across therapeutic modalities, disease targets, and indications
  • Implementation of computational chemistry toolkits (e.g., MOE, CCDC, Cresset) to run virtual screening campaigns to rapidly identify drug candidates for further development while proactively seeking and incorporating input from Medicinal Chemistry
  • Effective collaboration with the Biology and Medicinal Chemistry teams by providing key computational chemistry insights to aid in the Hit-to-Lead and Lead Optimization phases of drug discovery operations
  • Effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery as well as the incorporation of those models into drug discovery operations
  • Medicinal Chemistry
  • Biochemistry and biophysics
  • AI/ML applied to drug discovery
  • Existing tools, systems, and processes that currently support the 1910 Genetics team
  • Key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology
  • Our existing process for progressing from computational hit to experimental hit to lead to drug candidate
  • Propose a few hundred virtual hits to the Medicinal Chemists for synthesis
  • Progress a virtual hit to a biochemical/cellular hit
  • Co-author provisional patents on hit scaffolds
  • Validate a cellular hit in a clinically relevant animal model of disease
  • Update provisional patents with the animal model data
  • Nominate a lead candidate for progression into IND-enabling studies
1910 Genetics

11-50 employees

Website
Protein therapeutics biotech company
Company Overview
1910 Genetics is on a mission to use AI/ML to develop drugs against historically difficult disease targets. 1910 Genetics puts computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets.
Benefits
  • Extremely generous equity package
  • Competitive salary
  • Healthcare benefits
  • Generous vacation and parental leave
  • Super cool team building activities
  • Flexible work schedule