Proteomics Scientist @ Ginkgo Bioworks

INACTIVE

Full-Time

Proteomics Scientist

Posted on 3/6/2023

Ginkgo Bioworks

1,001-5,000 employees

Engineering biology for diverse commercial applications.

Food & Agriculture

Biotechnology

Consumer Goods

Mid

Dorchester, Boston, MA, USA

Required Skills

Data Analysis

Requirements

PhD degree in biochemistry, analytical chemistry, chemical engineering, biological sciences or equivalent and direct experience with proteomics analysis and MALDI/LC-MS operation, OR Master's degree in biochemistry, analytical chemistry, chemical engineering, biological sciences or equivalent and a minimum of 4 years of work experience in proteomics analysis and MALDI/LC-MS operation
Expertise in sample preparation, LC-MS operation/maintenance/troubleshooting, MALDI-TOF operation/maintenance/troubleshooting, and data analysis
Expertise in quantitative proteomics, such as targeted protein quantitation, global expression profiling, and TMT-based multiplexed workflows, to perform characterization of protein in complex sample matrices
Familiarity with common proteomics software and informatics pipelines
Ability to deeply understand processes, as well as adapt them in response to changing technologies and demands
Detail-oriented approach to meet varied co-occurring demands
Communicate clearly and timely with multiple stakeholders across multiple projects
Perform data analysis, interpretation, and presentation to key stakeholders

Responsibilities

Operate and improve processes for proteomic analysis of Ginkgo's strain libraries
Perform LC-MS equipment (e.g. nano-flow UHPLC, Orbitrap, qTOF) maintenance and troubleshooting
Perform MALDI-TOF equipment (e.g. Bruker MALDI-timsTOF) maintenance and troubleshooting
Refine and improve sample preparation and assay methods, including LHS automation
Develop processes for verification and quality control of assays to ensure low CV and high reproducibility
Use Ginkgo's Software and Automation infrastructure to execute assays and strain tests
Collaborate with software engineers to ensure that all generated data is captured, stored, and analyzed in Ginkgo's LIMS

Desired Qualifications

Experience with timsTOF is a plus
Experience with biological samples and fermentation is a plus
Experience with laboratory automation is a plus
Experience with scripting, databases, and automating data processing pipelines is a plus
Experience working with a mixed team of process engineers, biologists, and software developers

Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms.

Ginkgo applies the Design–Build–Test–Learn approach to organism engineering and the Omics and Analytical Chemistry team is uniquely situated at the Test team. We perform a central role in the team, interfacing with several other technical groups at Ginkgo. We use cutting edge analytical technologies for testing our engineered strains, characterizing biological parts and supporting the progress of programs on a wide array of fields, from natural products discovery to vaccine manufacturing. We’re seeking a highly skilled proteomics scientist to join our Test Team, where you will help to improve and scale our existing technologies, and define and develop the next set of analytical technologies that will lie at the center of our foundries.

As an ideal candidate for the Proteomics Scientist, Analytical biochemistry role, you will apply your expertise in mass spectrometry-based quantitative proteomics to the development, optimization, and execution of proteomics workflows that enable protein profiling across a wide variety of project teams, preferably in high throughput scale. You should possess a good foundation in LC-MS/MS and MALDI-TOF proteomics pipelines, method development, and troubleshooting. You will need attention to detail, the ability to collaborate across diverse teams. You should demonstrate the ability to evolve a process in response to changing technology and demands. In addition, any experience you have in a mixed team of process engineers, biologists, and software developers is a plus. #LI-LS1

Responsibilities

Operate and improve processes for proteomic analysis of Ginkgo’s strain libraries
Perform LC-MS equipment (e.g. nano-flow UHPLC, Orbitrap, qTOF) maintenance and troubleshooting
Perform MALDI-TOF equipment (e.g. Bruker MALDI-timsTOF) maintenance and troubleshooting
Refine and improve sample preparation and assay methods, including LHS automation.
Develop processes for verification and quality control of assays to ensure low CV and high reproducibility
Use Ginkgo’s Software and Automation infrastructure to execute assays and strain tests
Collaborate with software engineers to ensure that all generated data is captured, stored, and analyzed in Ginkgo’s LIMS

Minimum Requirements

PhD degree in biochemistry, analytical chemistry, chemical engineering, biological sciences or equivalent and direct experience with proteomics analysis and MALDI/LC-MS operation, OR Master’s degree in biochemistry, analytical chemistry, chemical engineering, biological sciences or equivalent and a minimum of 4 years of work experience in proteomics analysis and MALDI/LC-MS operation
Expertise in sample preparation, LC-MS operation/maintenance/troubleshooting, MALDI-TOF operation/maintenance/troubleshooting, and data analysis
Expertise in quantitative proteomics, such as targeted protein quantitation, global expression profiling, and TMT-based multiplexed workflows, to perform characterization of protein in complex sample matrices
Familiarity with common proteomics software and informatics pipelines
Ability to deeply understand processes, as well as adapt them in response to changing technologies and demands
Detail-oriented approach to meet varied co-occurring demands
Communicate clearly and timely with multiple stakeholders across multiple projects
Perform data analysis, interpretation, and presentation to key stakeholders

Preferred Capabilities and Experience

Experience with timsTOF is a plus
Experience with biological samples and fermentation is a plus
Experience with laboratory automation is a plus
Experience with scripting, databases, and automating data processing pipelines is a plus
Experience working with a mixed team of process engineers, biologists, and software developers

To learn more about Ginkgo, visit www.ginkgobioworks.com/press/ or check out some curated press below:

What is it really like to take your company public via a SPAC? One Boston biotech shares its journey (Fortune)

Ginkgo Bioworks resizes the definition of going big in biotech, raising $2.5B in a record SPAC deal that weighs in with a whopping $15B-plus valuation (Endpoints News)

Ginkgo Bioworks CEO on scaling up Covid-19 testing: ‘If we try, we can win’ (CNBC)

Ginkgo raises $70 million to ramp up COVID-19 testing for employers, universities (Boston Globe)

Ginkgo Bioworks Redirects Its Biotech Platform to Coronavirus (Wall Street Journal)

Ginkgo Bioworks Provides Support on Process Optimization to Moderna for COVID-19 Response (PRNewswire)

The Life Factory: Synthetic Organisms From This $1.4 Billion Startup Will Revolutionize Manufacturing (Forbes)

Synthetic Bio Pioneer Ginkgo Raises $290 Million in New Funding (Bloomberg)

Ginkgo Bioworks raises $350 million fund for biotech spinouts (Reuters)

Can This Company Convince You to Love GMOs? (The Atlantic)

We also feel that it’s important to point out the obvious here – there’s a serious lack of diversity in our industry, and that needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equity, and inclusion in all of its practices, especially when it comes to growing our team. Our culture promotes inclusion and embraces how rewarding it is to work with people from all walks of life.

We’re developing a powerful biological engineering platform, so we must remain mindful of the many ways our technology can – and will – impact people around the world. We care about how our platform is used, and having a diverse team to build it gives us the best chance that it’s something we’ll be proud of as it continues to grow. Therefore, it’s critical that we incorporate the diverse voices and visions of all those who play a role in the future of biology.

It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

Ginkgo Bioworks

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Ginkgo Bioworks, Inc. stands out as a leading bioengineering company that leverages advanced biological manufacturing technology to design and optimize a wide range of commercial products, from vaccines to sustainable fashion materials. The company's commitment to diversity, equity, and inclusion (DEI) fosters a unique and inclusive culture, promoting a diverse workforce that contributes to its success. Furthermore, Ginkgo's ability to engineer biology for equitable distribution of benefits positions it as a key player in various industries, including healthcare, agriculture, and fashion.

Company Stage

IPO

Total Funding

$2.4B

Headquarters

Boston, Massachusetts

Founded

2009

Growth & Insights

Headcount

6 month growth

↑ 6%

1 year growth

↑ 10%

2 year growth

↑ 63%

Benefits

Unlimited paid time off

Comprehensive health and parental leave benefits

Flexible work options

Commuter benefits

State-of-the-art labs, work spaces, and conference rooms

Competitive 401K contribution

INACTIVE