Full-Time
Confirmed live in the last 24 hours
$162k - $297kAnnually
Junior, Mid
Palo Alto, CA, USA + 2 more
More locations: San Jose, CA, USA | New York, NY, USA
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Company Size
1,001-5,000
Company Stage
Acquired
Total Funding
$739.4M
Headquarters
San Francisco, California
Founded
2006
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HONG KONG, Feb. 20, 2025 /PRNewswire/ -- Akeso, Inc. (9926.HK) ("Akeso" or the "Company") today announced the company has successfully enrolled the first patient in its multicenter, randomized, double-blind Phase III clinical trial of ivonescimab in combination with chemotherapy for first-line treatment for unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) (HARMONi-BC1/AK112-308). Ivonescimab is a first-in-class PD-1/VEGF bispecific antibody independently developed by the company.HARMONi-BC1/AK112-308 study is led by Professor Xu Binghe, a renowned breast cancer expert and academician of the Chinese Academy of Engineering, from the Cancer Hospital of the Chinese Academy of Medical Sciences. Preliminary efficacy data presented at the 2024 European Society for Medical Oncology (ESMO) Annual Meeting demonstrated that ivonescimab combined with chemotherapy showed significant therapeutic efficacy and also exhibited a favorable safety profile, underscoring its clinical potential for the treatment of locally advanced or metastatic TNBC.Akeso has strategically positioned ivonescimab within a comprehensive development plan, aiming to reshape the landscape of cancer immunotherapy and establish a new global standard of care. Ivonescimab, in combination with chemotherapy, has been approved in China for the treatment of EGFR-TKI-resistant, non-squamous NSCLC
Decrypt’s Art, Fashion, and Entertainment Hub. Discover SCENEWhat do you get when you combine EZBC and EZET? According to the launch of Franklin Templeton’s Crypto Index ETF, the result is EZPZ.Representing the ticker name of Franklin Templeton’s newest crypto product listed on the Cboe BZX exchange on Thursday, EZPZ offers investors both Bitcoin and Ethereum exposure.The product tracks price movements for the two top cryptocurrencies based on CF Benchmark’s Institutional Digital Asset Index, which debuted last year, and focuses on coins “recognized as being in conformance with major financial jurisdictions prevailing capital markets.”That means that instead of targeting just one cryptocurrency, the index weights top coins by market capitalization. As a result, 82% of a dollar invested in EZPZ would be exposed to Bitcoin’s price, while 18% would be correlated to Ethereum’s performance.EZPZ’s start follows Franklin Templeton’s introduction of spot Bitcoin and Ethereum ETFs last year. The financial giant, alongside its push into the digital assets space, first launched FOBXX, a tokenized money-market fund, on Polygon and Stellar in 2021.Roger Bayston, head of digital assets at Franklin Templeton, said in a press release that the fund’s 0.19% expense ratio will make it a cheap way for investors to tap a budding asset class.“Blockchains are emerging as important utilities for the current and future information and data economies,” he said. “With EZPZ, we’re offering a simple, low-cost way to gain exposure to this growing and important asset class.”Though Franklin Templeton ranks among the world’s largest asset managers, its Franklin Bitcoin ETF’s (EZBC) $708 million in assets under management (AUM) ranks just ninth among the 11 U.S.-based spot Bitcoin funds currently trading, according to CoinGlass data.BlackRock’s iShares Bitcoin ETF (IBIT), the dominant fund in the fledgling space, has $56.6 billion in AUM.The Franklin Ethereum ETF (EZET), which started trading alongside eight competitors last July, has $34 million in AUM to rank seventh among that group.Despite lesser adoption for Franklin Templeton's crypto ETFs, the firm’s digital assets arm is still, perhaps, at the forefront of crypto culture.Putting the fries in the bag. pic.twitter.com/oDxzAc2HVB — Franklin Templeton Digital Assets (@FTDA_US) February 18, 2025Earlier this week, Franklin Templeton Digital Assets posted a photo on X (formerly known as Twitter) of Benjamin Franklin wearing a hat that closely resembles a uniform at McDonald’s, which Crypto Twitter often portrays as an inevitable job for down-on-their-luck traders when markets are volatile.“Putting the fries in the bag,” the Wall Street bank said.Edited by James Rubin
Decrypt’s Art, Fashion, and Entertainment Hub. Discover SCENEEthereum gaming franchise Illuvium has undergone a company restructuring, resulting in layoffs along with some core contributors opting to take pay cuts or receive their wages in the gaming IP’s own token.The downsizing comes after Illuvium released a trio of interconnected games last year—Overworld, Arena, and Zero—that covered varying genres. Despite its ambitious vision, the community's reaction wasn't overwhelmingly positive following years of development.In December, co-founder Kieran Warwick admitted that "concerns" about the franchise's gameplay were valid and that things had to change. Part of this included that Illuvium had "significantly" reduced its costs via capping wages at $85,000, among other adjustments.But this week, Warwick said that more substantial cuts had to be made.💥Hard Decisions Shape the Brightest Futures💫 Major updates on the Illuvium team, strategy, and what comes next. Everything you need to know is in the message below from @KieranWarwick! 👇 pic.twitter.com/h2L9JK6IB5 — Illuvium (@illuviumio) February 19, 2025"We made the difficult decision to restructure our core contributor team to bring our monthly burn rate closer to $500,000," Warwick said in a Tuesday statement. "We want to extend our sincere gratitude to everyone affected by these changes."The statement on X (formerly Twitter) further explains that some employees have "generously offered" to take pay cuts, while others have chosen to receive their salary in the project's ILV token rather than the USDC stablecoin
Decrypt’s Art, Fashion, and Entertainment Hub. Discover SCENEDespite favorable odds for approval, the debut of exchange-traded funds based on the price of Solana in the U.S. is far from certain pending regulatory review, ongoing enforcement actions, and public comment on the multiple filings.A lot can change for Solana hopefuls before they potentially start trading.“Right now, the only thing that's happened is they didn't get a phone call telling them to go away,” Bloomberg Senior ETF Analyst Eric Balchunas told Decrypt.The SEC began weighing applications for spot Solana ETFs this week. In this case, its deadline—which the agency has brushed up against in approving other crypto funds—can be extended as late as Oct. 16.The Solana ETFs would further broaden access to digital asset-focused products following the dramatic success of spot Bitcoin and Ethereum ETFs since their respective approvals last year. Those funds enabled traditional financial institutions to invest billions of dollars in the top two cryptocurrencies and sent crypto markets upward.Among major asset managers, Grayscale, Bitwise, Canary, 21Shares, and VanEck have all filed applications for spot Solana ETFs with the SEC.Balchunas has penciled in a 70% chance that Solana ETFs are approved this year
Argentinian President Javier Milei said it would be “an honor” for Argentina to host the next edition of Devconnect, a gathering of independent events that foster the growth of the Ethereum ecosystem.Milei made the statement in response to Vitalik Buterin’s praise of Argentina’s Ethereum community. He said the energy and determination of builders based in the country are real and the event should be held there.The Ethereum co-founder assessed that the recent LIBRA memecoin scandal should not be seen as a reason to stop believing in crypto but as a motivation to spread education.He added:“I continue to be very optimistic about Argentina and Latam’s contributions and role in the space.”In another X post, Buterin suggested that the next edition of Devconnect should be hosted in Argentina. He said this could be a “great opportunity” to showcase good examples of crypto usage to the Argentinian community and then tagged Milei in the post.Milei responded via social media:“THANK YOU VERY MUCH VITALIK BUTERIN FOR YOUR WORDS ABOUT ARGENTINE TALENT!!! It would be an honor for Argentina to host Devconnect. I agree that it would be a great opportunity for our country.”According to Chainalysis’ “2024 Geography of Crypto Report,” Argentina has the 15th-largest crypto adoption index and leads Latin America in crypto value received, at an estimated $91.1 billion between 2023 and 2024.LIBRA controversyThe interactions between the Argentinian President and the Ethereum co-founder come in the backdrop of significant controversy. Milei endorsed the memecoin LIBRA on Feb. 14, saying the token was a way to fund Argentinian ventures.The token reached a $4.5 billion valuation before crashing 95% over the weekend