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Full-Time

Director/Sr. Director

Clinical Pharmacology & Pharmacometrics

Posted on 4/10/2024

Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals

501-1,000 employees

Develops RNAi-based therapies for diseases

Biotechnology
Healthcare

Compensation Overview

$220k - $300kAnnually

Senior

Madison, WI, USA + 2 more

More locations: Pasadena, CA, USA | San Diego, CA, USA

Category
Physicians & Surgeons
Medical, Clinical & Veterinary
Required Skills
Communications
Requirements
  • PhD or equivalent in pharmacokinetics, pharmacology or pharmaceutical science
  • Track records in clinical pharmacology program leadership with 7+ years of pharmaceutical/Biotech industry experience
  • Established knowledge of drug development from Pre-INA to NDA/BLA
  • Ability to apply scientific principles to complex situations and provide effective solutions
  • Strong verbal communication and document writing skills with clarity of thinking
  • Proficiency in non-compartmental analysis of clinical PK data
Responsibilities
  • Lead the function of Clinical Pharmacology/Pharmacometrics for multiple programs in Phase 1-3 development
  • Contribute to clinical protocols design and execution; analyze data and prepare clinical study reports
  • Participate in regulatory interactions with global Health Authorities and prepare documents with submission standards
  • Maintain a current understanding of field literature for oligonucleotide therapeutics, and Model-Informed Drug Development (MIDD)
  • Provide PK/PD Modeling & Simulations to support dosing strategies for clinical programs
  • Provide leadership expertise and mentor junior team members
Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals

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Arrowhead Pharmaceuticals develops medicines aimed at treating severe diseases by targeting and silencing specific genes. The company uses RNA interference (RNAi), a natural process that reduces gene expression, to create therapies that can potentially stop or reverse diseases like cystic fibrosis and hepatitis B. Their approach involves a variety of RNA chemistries and effective delivery methods to ensure that the target genes are significantly reduced in activity. Unlike many competitors, Arrowhead focuses specifically on RNAi-based therapies, which allows them to address medical needs that are not met by existing treatments. The goal of Arrowhead Pharmaceuticals is to provide new treatment options for patients suffering from genetic disorders, leveraging their expertise and partnerships to bring these therapies to market.

Company Stage

IPO

Total Funding

$899.9M

Headquarters

Pasadena, California

Founded

2004

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Simplify's Take

What believers are saying

  • Arrowhead's recent $450 million funding round provides substantial financial resources to advance its drug pipeline and expand research initiatives.
  • Positive Phase 2 data for plozasiran and the initiation of an Expanded Access Program highlight the company's commitment to addressing unmet medical needs.
  • The company's diversified pipeline, including treatments for cystic fibrosis, hepatitis B, and myotonic dystrophy, offers multiple avenues for success.

What critics are saying

  • The high costs and lengthy timelines associated with drug development could strain Arrowhead's financial resources despite recent funding.
  • Regulatory hurdles and the potential for clinical trial failures pose significant risks to the company's drug approval process.

What makes Arrowhead Pharmaceuticals unique

  • Arrowhead Pharmaceuticals leverages RNA interference (RNAi) technology to target and silence disease-causing genes, setting it apart from traditional pharmaceutical approaches.
  • The company's proprietary TRiM platform enables tissue-specific targeting, enhancing the efficacy and safety of its therapies.
  • Strategic partnerships with major pharmaceutical companies like Takeda bolster Arrowhead's credibility and expand its research capabilities.

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