Facebook pixel

Senior Scientist I
Non-Viral Delivery
Confirmed live in the last 24 hours
Locations
San Bruno, CA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Requirements
  • Bachelor's degree in related field and 8+ years industry experience (or Master's degree and 6+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 2+ years of industry experience)
  • Expertise in LNP formulation screening and optimization
  • Expertise in using design of experiment (DOE), relevant statistical softwares (JMP), and predictive analytics for formulation discovery
Responsibilities
  • Lead DOE-based LNP formulation screening/discovery campaigns directed toward in vivo and ex vivo delivery of Mammoth's proprietary CRISPR-based gene editing systems
  • Design, implement and execute early process development activities for LNP scale-up
  • Critically review and analyze data, and communicate results and conclusions; present and defend ideas in cross-functional meetings
  • Explore and evaluate non-viral delivery technologies for various therapeutics indications
  • Explore new orthogonal characterization assays and rigorously QC all the test articles
  • Manage the non-viral delivery projects to support deliverables along established timelines
  • Train, guide, and manage the researchers on various non-viral delivery activities
Desired Qualifications
  • Exposure to LNP scale-up and process development activities
  • Hands-on expertise in various basic analytical and biophysical methods/assays of LNP characterization such as, particularly size, zeta potential, and nucleic acid encapsulation/release, PKa, etc
  • Foundation in experimental documentation, basic statistical analysis and data presentation
  • Experience working with internal and external research collaborators and CROs
  • Highly motivated, hard working, and collaborative spirit
Mammoth Biosciences

11-50 employees

CRISPR disease detection biotech company