Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what’s possible in genetic medicine and work to make a lasting impact on human health.
Position Summary:
We are seeking a passionate and creative Associate Scientist to join our Disease Area Biology team and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company. The successful candidate will have a strong background in standard cell and molecular biology techniques.
Key Responsibilities:
- Responsible for the design, execution and analysis of a variety of in vitro cellular and molecular biology assays, focused on understanding and optimizing our ADAR-mediated RNA editing platform
- Evaluate and troubleshoot new assays and techniques, as well as balancing a variety of tasks
- Participate in the development and scaling of novel cell-based assays
- Deployment of cell-based models and assays for drug candidate screening and mechanism of action understanding
- Design, validate and implement high throughput NGS, dPCR and qPCR-based assays
- Design and implement thoughtful and well-controlled experiments
- Work with various types of automated high throughput equipment
Required Qualifications:
- MS (3+ years’ experience) /BS (5+years’ experience) in molecular and/or cellular biology, or a related field
Other Knowledge, Experience, and Skills Recommended:
- Broad experience in the application of biochemical, biophysical & cell-based techniques such as mammalian cell culture, transfections, Western blotting, Simple Western, plate-based assays, probe-based qPCR and dPCR
- Experience in oligonucleotide therapeutics is a plus
- Familiarity in the use of lab automation
- Must be able to analyze, report and communicate data rigorously
- The ability to learn and implement new techniques and adapt rapidly are essential
- Excellent attention to detail, time management, and documentation
- Ability to multitask and successfully interact with a diverse team of scientists to deliver quality data and results
- Clearly present research updates to cross-functional project teams
- Motivated team player
- Strong interpersonal and communication skills (Oral/Written)
- Ability to balance multiple high-priority tasks in a rapidly changing environment
Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.