Full-Time

Principal Site Reliability Engineer

Posted on 11/1/2025

Amgen

Amgen

10,001+ employees

Biotech company creating biologic medicines

No salary listed

Hyderabad, Telangana, India

In Person

Category
DevOps & Infrastructure (2)
,
Required Skills
Kubernetes
Python
Docker
AWS
Jenkins
Terraform
Ansible
Requirements
  • Master’s degree and 8 to 10 years of IT infrastructure, Site Reliability Engineering or related fields experience OR
  • Bachelor’s degree and 10 to 14 years of IT infrastructure, Site Reliability Engineering or related fields experience OR
  • Diploma and 14 to 18 years of IT infrastructure, Site Reliability Engineering or related fields experience.
  • Extensively experienced with AWS Cloud Services
  • Proficient in CI/CD (Jenkins/Gitlab), Observability, Infrastructure as Code, GitOps etc
  • Experience with containerization (Docker) and orchestration tools (Kubernetes) to optimize resource usage and improve scalability.
  • Identify and specify SRE tasks
  • Strong hands-on SRE tasks and automate using Python/Scripting language
  • Well versed with FinOps, Infra-Ops, & Platform Operations.
  • Ability to learn new technologies quickly. Strong problem-solving and analytical skills. Excellent communication and teamwork skills.
  • Leadership skills are mandatory to lead a team of 4 to 5 to guide on Technical blockers
Responsibilities
  • System Reliability, Performance Optimization & Cost Reduction: Ensure the reliability, scalability, and performance of Amgen’s infrastructure, platforms, and applications. Proactively identify and resolve performance bottlenecks and implement long-term fixes. Continuously evaluate system design and usage to identify opportunities for cost optimization, ensuring infrastructure efficiency without compromising reliability.
  • Automation & Infrastructure as Code (IaC): Drive the adoption of automation and Infrastructure as Code (IaC) across the organization to streamline operations, minimize manual interventions, and enhance scalability. Implement tools and frameworks (such as Terraform, Ansible, or Kubernetes) that increase efficiency and reduce infrastructure costs through optimized resource utilization.
  • Standardization of Processes & Tools: Establish standardized operational processes, tools, and frameworks across Amgen’s technology stack to ensure consistency, maintainability, and best-in-class reliability practices. Champion the use of industry standards to optimize performance and increase operational efficiency.
  • Monitoring, Incident Management & Continuous Improvement: Implement and maintain comprehensive monitoring, alerting, and logging systems to detect issues early and ensure rapid incident response. Lead the incident management process to minimize downtime, conduct root cause analysis, and implement preventive measures to avoid future occurrences. Foster a culture of continuous improvement by leveraging data from incidents and performance monitoring.
  • Collaboration & Cross-Functional Leadership: Partner with software engineering, and IT teams to integrate reliability, performance optimization, and cost-saving strategies throughout the development lifecycle. Act as a SME for SRE principles and advocate for best practices for assigned Projects.
  • Capacity Planning & Disaster Recovery: Execute capacity planning processes to support future growth, performance, and cost management. Maintain disaster recovery strategies to ensure system reliability and minimize downtime in the event of failures.
Desired Qualifications
  • Knowledge of cloud-native technologies and strategies for cost optimization in multi-cloud environments.
  • Familiarity with distributed systems, databases, and large-scale system architectures.
  • Bachelor’s degree in computer science and engineering preferred, other Engineering field is considered
  • Databricks Knowledge/Exposure is good to have (need to upskill if hired)
  • Soft Skills: Ability to foster a collaborative and innovative work environment.
  • Soft Skills: Strong problem-solving abilities and attention to detail.
  • Soft Skills: High degree of initiative and self-motivation.

Amgen develops medicines that treat serious illnesses by using biologic therapies made from living cells. These therapies are designed to target specific disease processes, such as cancer, cardiovascular disease, and autoimmune conditions, and are produced through biotechnology methods that create proteins or antibodies. Amgen’s products are sold to patients and healthcare providers worldwide, with revenue funding ongoing research and development to discover new treatments. The company stands out by focusing on biologic medicines at a large scale and maintaining a steady pipeline of potential therapies across multiple disease areas, supported by global manufacturing and a commitment to bringing therapies to patients. Its goal is to improve patient outcomes by discovering and delivering new, effective treatments while reinvesting a significant portion of earnings into research and development.

Company Size

10,001+

Company Stage

IPO

Headquarters

Thousand Oaks, California

Founded

1980

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Simplify's Take

What believers are saying

  • Tarlatamab wins China NMPA approval May 2026 for $2B+ sales potential.
  • Q1 2026 revenues hit $8.6B with 16 brands posting double-digit growth.
  • Zai Lab partners on DLL3-ADC plus IMDELLTRA for SCLC trials.

What critics are saying

  • Prolia sales drop 34% to $727M from biosimilar competition in Q1 2026.
  • FDA warns Tavneos causes liver injuries, proposes approval withdrawal.
  • Horizon drugs Tepezza, Uplizna, Krystexxa underperform 19 months post-acquisition.

What makes Amgen unique

  • Amgen's BiTE platform establishes IMDELLTRA as second-line SCLC standard.
  • MariTide advances in Phase III obesity trials with monthly dosing.
  • UPLIZNA surges 73% post-IgG4 and gMG approvals in 2025.

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Benefits

Professional Development Budget

Conference Attendance Budget

Company News

Yahoo Finance
Apr 10th, 2026
Amgen's lung cancer drug tarlatamab wins China approval, seen as $2B+ opportunity

Amgen's lung cancer drug tarlatamab has received approval from China's National Medical Products Administration, according to its development partner BeOne Medicines. The drug is a targeted immunotherapy for adults with extensive-stage small cell lung cancer that has progressed despite chemotherapy. Sold as Imdelltra in the US, tarlatamab is a bispecific antibody designed to connect cancer cells with immune cells, enabling the body's immune system to destroy the cancer. Neither Amgen nor Hong Kong-listed BeOne provided details on launch date or pricing for the Chinese market. Wall Street analysts estimate tarlatamab could generate annual sales exceeding $2 billion for Amgen.

Yahoo Finance
Apr 3rd, 2026
Amgen faces Tavneos liver injury warning as Zai Lab oncology collaboration expands IMDELLTRA pipeline

Amgen faces fresh safety concerns after the FDA warned of severe liver injuries, including vanishing bile duct syndrome, linked to Tavneos (avacopan) in late March 2026. The development adds regulatory risk to the company's investment profile. Separately, Zai Lab announced a global collaboration with Amgen to test its DLL3-targeting ADC alongside Amgen's IMDELLTRA in extensive-stage small cell lung cancer, underscoring the company's ongoing oncology expansion through external partnerships. Amgen's narrative projects $37.4 billion revenue and $8.2 billion earnings by 2028, requiring 2.3% yearly revenue growth. However, pessimistic analysts model revenues slipping to $34.4 billion with earnings near $5.2 billion, reflecting concerns around pricing pressure, biosimilar competition and rising research and development spend alongside the new safety issues.

Yahoo Finance
Mar 30th, 2026
Amgen stock up 24% since Jim Cramer's June recommendation, beats earnings estimates

Amgen, one of the world's largest pharmaceutical companies, has seen its shares rise 24% since Jim Cramer discussed the stock on Mad Money in June 2025. The company is currently developing the weight loss drug MariTide. Amgen's shares jumped 7.5% in November 2025 after posting third-quarter results that beat analyst expectations, with $9.6 billion in revenue and $5.64 earnings per share against forecasts of $8.98 billion and $5.04 respectively. In February 2026, shares rose 8% following fourth-quarter earnings that also exceeded estimates. Cramer expressed cautious optimism about the biotech company, noting its mid-single-digit earnings growth and potential upside from its GLP-1 drug development. Whilst calling Eli Lilly his preferred GLP-1 play, Cramer said investors "could do a lot worse than Amgen" for a bargain option.

Yahoo Finance
Mar 25th, 2026
Wells Fargo lifts Amgen price target to $390, cites $20B myasthenia gravis market potential by 2036

Wells Fargo has raised its price target on Amgen to $390 from $375, maintaining an Equal Weight rating. The firm cited emerging therapies including CD20, BAFF/APRIL and next-generation complement inhibitors as potential drivers that could expand the generalized myasthenia gravis market threefold over the next decade, potentially reaching $15 billion in US sales and $20 billion globally by 2036. Separately, Jefferies initiated coverage on Amgen with a Hold rating and $350 price target on 10 March, noting the stock has gained approximately 35% over the past six months. Last month, Amgen reported fourth-quarter adjusted earnings per share of $5.29, beating the $4.76 consensus estimate, on revenue of $9.9 billion versus $9.45 billion expected.

Yahoo Finance
Mar 15th, 2026
Amgen joins TrumpRx discount scheme and lifts dividend to $2.52 per share

Amgen has announced a $2.52 per-share second-quarter dividend and joined the government-run TrumpRx platform to offer discounted drugs including Amjevita, Aimovig and Repatha. The company is also preparing for its 11 March presentation at the Leerink Global Healthcare Conference in Miami. The moves come alongside double-digit revenue and earnings per share growth in 2025 and advances in obesity and oncology programmes. However, the TrumpRx discounting could pressure net pricing as Amgen invests heavily in late-stage trials and manufacturing expansion. Amgen's narrative projects $37.4 billion revenue and $8.2 billion earnings by 2028, requiring 2.3% yearly revenue growth. Some analysts see a tougher outlook, with revenue potentially drifting towards $34.4 billion and earnings around $5.2 billion.

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