Job Description Summary
The successful candidate will be a highly motivated individual with excellent analytical and communication skills who has an interest in studying therapeutic resistance in cancer. The goal of our research program is to understand the complex signaling networks that control hypoxia-mediated therapeutic resistance in solid tumors and translate these basic concepts to clinical applications that will directly impact patient care. We study tumor hypoxia with human cancer cells, using diverse methodology, including protein biochemistry, live cell imaging, HTS approaches, and in vivo models. The position requires the supervision of key laboratory procedures and conducting independent research in conjunction with the Principal Investigator, and to train undergraduate, graduate, medical students, postdocs, and visiting scholars.
Entity
Medical University of South Carolina (MUSC - Univ)
Worker Type
Employee
Worker Sub-Type
Research Grant
Cost Center
CC000954 COM BIOCHEM Operations CC
Pay Rate Type
Salary
Pay Grade
University-00
Pay Range
0.00 - 0.00 - 0.000
Scheduled Weekly Hours
40
Work Shift
Job Description
Job Description:
Applications are invited for a full-time Staff Scientist position available in the Warfel lab in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina and Hollings Cancer Center.
The successful candidate will be a highly motivated individual with excellent analytical and communication skills who has an interest in studying therapeutic resistance in cancer. The goal of our research program is to understand the complex signaling networks that control hypoxia-mediated therapeutic resistance in solid tumors and translate these basic concepts to clinical applications that will directly impact patient care. We study tumor hypoxia with human cancer cells, using diverse methodology, including protein biochemistry, live cell imaging, HTS approaches, and in vivo models. The position requires the supervision of key laboratory procedures and conducting independent research in conjunction with the Principal Investigator, and to train undergraduate, graduate, medical students, postdocs, and visiting scholars.
A PhD with minimum four years postdoctoral experience is desired.
Additional Knowledge, Skills, and Abilities desired: Experience with biochemistry and molecular biology techniques and knowledge of reporter assay design and development. Previous experience culturing human cells in vitro and working with animal models of cancer. Demonstrated ability to work independently and in a team; specifically, the candidate must be able to design and execute properly controlled biological experiments independently. Preference will be given to candidates with a background in signal transduction pathways and cancer biology. Excellent written and verbal communication skills and exceptional time management and
Preferred Qualifications:
- Perform, analyze, interpret and communicate data generated from model systems involving hypoxia using a range of biochemical techniques (35%)
- Management of mouse colonies and performing a variety of animal experiments to test drug efficacy and biology (20%).
- Preparation of reagents; maintaining correct up to date laboratory notebooks, compliance with biosafety regulations, protection of human subjects and laboratory animal regulations; ordering supplies; and maintaining lab equipment (20%)
- Work closely with PI and collaborators to work on manuscripts and develop new research grant proposals. (15%)
- Oversee and assist technicians, graduate students, visiting scholars and post docs involved in imaging research (10%)
Additional Job Description
Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs., unassisted. (Frequent) Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 30 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 50 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.
If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees
Biology & Biotech (5)