AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.

We are looking for a highly motivated Principal Scientist with a strong oncology and immunology background to join our team. You will contribute to the assessment and development of antibody-based oncology drug candidates so that we can move programs faster and with less risk to the clinic. You are someone who has a passion for understanding how models can predict therapeutic action on human disease, and here you will be involved in both internal R&D as well as external collaborative research. 

How you might spend your days:

• Leading internal preclinical in vivo oncology models to support oncology programs
• Designing, supporting, and interpreting pharmacology studies to generate in vivo proof-of-concept and build confidence in selection of molecules for clinical development
• Collaborating with in vitro biology, protein engineering, and pharmacokinetics scientists, as well as external CROs and collaborators, to execute efficient PK/PD studies to identify lead molecules and advance programs to human trials 
• Mentoring team members in laboratory techniques related to tumour xenograft models
• Reporting findings to internal program teams and partners to support data-driven decisions
• Evaluating available preclinical and clinical data sets to build testable biological hypotheses for oncology targets and then preclinically assessing those hypotheses
• Developing and overseeing supporting assays to assess target modulation and downstream effects at the cellular, protein, and gene level

We’d love to hear from you if: 

• You have 10+ years of hands-on experience in oncology, immuno-oncology, and biologics drug development
• You have a PhD in Pharmacology, Immunology, or related field, plus 10+ years of experience in a biopharmaceutical industry setting; if you have a MSc and 15 years of relevant experience, you will also be considered 
• You have proven interpersonal skills and create value on cross-functional teams
• You are genuinely curious, with an interest in discussing innovative ideas in a highly collaborative and fast paced environment
• You are good at communicating scientific and/or technical concepts with an emphasis on application
• You are able to independently identify project needs and follow that up with constructing and implementing solutions
• You enjoy the teamwork that comes with working on complicated biological questions and building data sets that help to predict the success of therapies

What we offer:

AbCellera’s hiring range for this role is CAD $141,600 - $177,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution. 

You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find we prioritize teams and social groups to build community and connections across AbCellera.

About AbCellera:

AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.

And it all starts with our team. We’ve built a place where people feel they are part of something bigger than themselves. A place that exists to push the limits of science and technology, and aims to bring better therapies to patients.

We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success. 

To apply:

Please submit your application through our website and refer to Job ID 23216-D in your cover letter. We apologize in advance, but we receive a large volume of applications and are only able to contact those who are selected for an interview.

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