Full-Time

Scientist II

Conjugation Development

Posted on 5/23/2024

Vaxcyte

Vaxcyte

201-500 employees

Develops broad-spectrum bacterial infection vaccines

Biotechnology

Mid

San Carlos, CA, USA

Requirements
  • PhD in chemistry, biochemistry, or related field with 2-5+ years of industry experience, MS with 5-8+ years, or BS with 10+ years of experience
  • Strong biochemistry and organic chemistry knowledge base underpinning several years’ experience preparing bioconjugates
  • Proficiency with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration
  • Proficiency in a variety of techniques for bioconjugate analysis such as colorimetric assays, HPLC, and SEC-MALS
  • Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods
  • Experience with Design of Experiments is desirable
  • Experience with chemical modification of polysaccharides is desirable
  • Experience implementing and/or using electronic notebooks is desirable
  • Attention to detail and excellent organizational skills
  • Strong interpersonal skills; ability to communicate effectively both verbally and in written formats
  • Self-starter; ability to work in a fast-paced, cross-functional environment and collaborate effectively with other team members
  • Enthusiasm to learn the new skills and techniques necessary to tackle problems outside of current area of expertise
Responsibilities
  • Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates
  • Purify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF)
  • Analyze polysaccharides and conjugates with a variety of analytical methods
  • Develop new laboratory workflows and analyses beyond established procedures when appropriate
  • Advise team members on experimental design, interpretation of results, and troubleshooting
  • Model and train team members on best practices for adherence to protocols and data management
  • Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations
  • Maintain highly organized records to enable optimization and assessment of reproducibility
  • Attend team meetings ready to provide updates on conjugation development progress

Vaxcyte is centered on creating advanced vaccines such as VAX-24, a sophisticated 24-valent pneumococcal conjugate vaccine, by utilizing cutting-edge chemistry and the XpressCF™ cell-free protein synthesis platform. The company prioritizes developing high-fidelity, broad-spectrum vaccines to combat bacterial infections, continuously expanding its product pipeline with innovations like VAX-31 for various bacterial threats.

Company Stage

IPO

Total Funding

$2.3B

Headquarters

San Carlos, California

Founded

2013

Growth & Insights
Headcount

6 month growth

29%

1 year growth

61%

2 year growth

166%