Full-Time

Sr. Associate Engineer

Polysaccharide Process Development

Updated on 4/25/2024

Vaxcyte

201-500 employees

Develops broad-spectrum pneumococcal conjugate vaccines

Biotechnology

Mid

San Carlos, CA, USA

Required Skills

Python

Excel/Numbers/Sheets

PowerPoint/Keynote/Slides

Requirements

B.S./M.S. in bioengineering, chemical engineering, biochemistry or related disciplines with 3+ years of experience
Prior experience with bioreactor fermentations, depth filtration, centrifugation, and TFF for primary recovery
Experience with analytical methods such as plate-based assays, UV-spectrophotometry, and metabolite analyzers
Experience writing technical documents including lab operation protocols and data summary reports
Proficiency in Microsoft Excel, Word, and Powerpoint
Experience with statistical software such as JMP, R studio, python, etc.
Familiarity with statistical methods for process characterization and validation
Familiarity with DOE principles and experience with DoE software (JMP)
Some experience with GXP requirements including deviation investigations, CAPAs, and change controls
Understanding of engineering principles for scaling upstream unit operations

Responsibilities

Assist in designing and executing process development runs
Operate and maintain instrumentation including BSL2 microbial fermenters, TFF systems, depth filtration, and centrifugation
Record data in electronic laboratory notebooks and write technical summary reports
Perform analytical assays for process development and in-process manufacturing samples
Perform statistical analysis for manufacturing in-process data
Present data to the team and contribute to technical discussions
Review manufacturing documents and transfer in-process data to repositories

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Essential Functions:

Assist in designing and executing process development runs focusing on scale down modeling and late-stage process characterization of upstream and primary recovery steps.
Operate and maintain instrumentation including BSL2 microbial fermenters, TFF systems, depth filtration and centrifugation.
Record data in electronic laboratory notebooks, and aid in writing technical summary reports.
Perform analytical assays for process development and in-process manufacturing samples and maintain manufacturing and process development data repositories.
Perform statistical analysis for manufacturing in-process data for manufacturing process insights and characterization purposes.
Present data to the team to provide updates on small scale development activities and contribute to technical discussions.
Perform scaling calculations between large scale manufacturing and small-scale process development operations.
Review manufacturing documents and transfer in-process data to data repositories.

Requirements:

B.S./M.S. in bioengineering, chemical engineering, biochemistry or other related disciplines with 3+ years of experience.
Prior experience with bioreactor fermentations, including glass and single use vessels, as well as experience with depth filtration, centrifugation, and TFF for primary recovery.
Experience with analytical methods such as plate-based assays, UV-spectrophotometry, and metabolite analyzers.
Experience writing technical documents including lab operation protocols and data summary reports.
Proficiency in computer programs including Microsoft Excel, Word, and Powerpoint.
Experience with statistical software such as JMP, R studio, python, etc. for manufacturing process analytics.
Familiarity with statistical methods for process characterization and validation is a plus.
Familiarity with DOE principles and experience with DoE software (JMP) is a plus.
Some experience with GXP requirements including deviation investigations, CAPAs, and change controls.
Understanding of engineering principles for scaling upstream unit operations.

Reports to: MSAT Engineer II, Polysaccharide

Location: San Carlos, CA

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $107,000 – $123,000

Send resumes to:

[email protected]

Vaxcyte, Inc.

825 Industrial Road, Suite 300

San Carlos, CA 94070

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

Vaxcyte

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Vaxcyte is dedicated to developing a range of high-fidelity, broad-spectrum vaccines, including VAX-24, a 24-valent pneumococcal conjugate vaccine. Leveraging advanced chemistry and the proprietary XpressCF™ cell-free protein synthesis platform, the company stands out in the biotechnology field for its targeted approach to combating serious bacterial infections. This focus on cutting-edge technology and a strong pipeline of innovative vaccine candidates makes it an exciting workplace for professionals passionate about impacting global health through scientific breakthroughs.

Company Stage

IPO

Total Funding

$2.3B

Headquarters

San Carlos, California

Founded

2013

Growth & Insights

Headcount

6 month growth

↑ 25%

1 year growth

↑ 60%

2 year growth

↑ 150%