Full-Time

AI & Intelligent Systems Enablement Manager

Posted on 9/11/2026

Deadline 9/19/26
Pfizer

Pfizer

10,001+ employees

Biopharmaceutical company develops medicines and vaccines

Compensation Overview

$99.2k - $165.4k/yr

+ 12.5% bonus target + Share-based long-term incentive program

No H1B Sponsorship

Sanford, NC, USA

Hybrid

Hybrid work arrangement.

Bachelor's, Master's, PhD, Associate's

Category
Software Engineering (1)
Required Skills
LLM
Power BI
SQL
SAP Products
Data Engineering
RAG
Observability
LangChain

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Requirements
  • A Bachelor's degree in Computer Science, Data Science, Engineering, or a related field with at least 4 years of experience; or a Master's degree with more than 2 years of experience; or a PhD with 0 years of experience; or a High School Diploma or equivalent with 10 years of relevant experience; or an Associate's degree with 8 years of experience.
  • Experience in AI/ML solution development, data engineering, or digital solutions delivery.
  • Hands-on experience with large language models and orchestration frameworks such as LangChain or OpenAI APIs for building agentic workflows.
  • Experience designing tool-augmented agents using function calling, retrieval-augmented generation, memory systems, and planning/execution loops.
  • Working knowledge of vector databases, embeddings, and retrieval systems for accurate, scalable knowledge retrieval.
  • Experience applying prompt engineering, evaluation, and guardrail techniques such as hallucination mitigation and output validation to production-grade AI systems.
  • Experience with low-code/no-code platforms such as Power BI and Power Automate.
  • Demonstrated experience assessing data quality and readiness, including completeness, accuracy, consistency, and timeliness, for analytics or AI use cases.
  • Proficiency in SQL or equivalent tools for querying and profiling data directly from source systems.
  • Understanding of differing data-quality requirements across retrieval-based, predictive, and generative AI approaches.
  • Familiarity with site operational systems such as LIMS, SAP, EAMS, and quality management systems.
  • Ability to translate technical capability into business value for non-technical stakeholders.
  • Ability to operate across strategic advisory work and hands-on technical delivery.
Responsibilities
  • Design and develop AI-enabled solutions for approved business needs, including retrieval-augmented generation solutions and generative AI use cases.
  • Integrate AI into existing digital products where it measurably improves business value.
  • Assess data availability and quality relevant to digital or AI applications.
  • Work with data owners to close data gaps needed for reliable AI outcomes.
  • Identify opportunities to simplify and digitize workflows.
  • Support technology-enabled process improvements alongside Continuous Improvement Specialists and Improvers.
  • Recommend and implement continuous-improvement initiatives.
  • Advise site leadership on AI-appropriate applications.
  • Develop roadmaps that integrate emerging technologies into manufacturing operations.
  • Recommend investments that strengthen AI and long-term digital performance.
  • Partner with business functions to identify digital improvement needs.
  • Guide project scoping, feasibility assessment, and technology selection.
  • Ensure initiatives follow the site's standard project intake and governance process.
  • Deliver awareness sessions and training to build digital and AI capability across colleagues.
  • Support upskilling initiatives aligned with the site's Digital Workforce framework.
  • Ensure solutions comply with corporate governance, security, validation, and responsible-AI requirements.
  • Promote appropriate use of AI across the site and document governance decisions.
  • Monitor industry trends in emerging AI technologies and platform developments.
  • Evaluate new tools for potential site adoption.
  • Share best practices with Digital Engineering and site leadership.
  • Maintain awareness of evolving regulatory and governance expectations.
Desired Qualifications
  • Experience in pharmaceutical, biotech, or other regulated manufacturing environments, including GxP or computer system validation.
  • Exposure to AI governance or responsible-AI frameworks.
  • Experience training or upskilling colleagues on new digital tools.
  • Awareness of production AI system considerations such as latency, cost efficiency, and observability.

Pfizer is a global biopharmaceutical company that discovers, develops, manufactures, and sells medicines and vaccines for a range of health needs, including vaccines, oncology, and other specialized therapies. Its products work by using biological mechanisms to prevent or treat diseases—vaccines train the immune system to fight infections, while medicines target cancer and other conditions. Pfizer differentiates itself through its large worldwide footprint, broad portfolio across multiple therapeutic areas, and partnerships (notably with BioNTech) that expanded its reach in vaccines and cutting-edge therapies. The company also engages in public health initiatives, such as efforts to provide vaccines to underserved populations. Pfizer’s broad goal is to improve global health by delivering safe and effective medicines and vaccines through research, development, and wide international distribution.

Company Size

10,001+

Company Stage

IPO

Headquarters

New York City, New York

Founded

1849

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Simplify Jobs

Simplify's Take

What believers are saying

  • Q2 2026 revenue rose to $15 billion, and non-COVID products grew 5% operationally.
  • Pfizer raised 2026 guidance to $60.5 billion-$62.5 billion after Eliquis, Padcev, Vyndaqel strength.
  • Berobenatide entered Phase 3 planning, giving Pfizer a credible obesity franchise before 2028.

What critics are saying

  • Depo-Provera MDL exceeded 5,800 cases by July 2026, with late-2026 bellwethers looming.
  • Vyndamax still faces Apotex litigation in Delaware, preserving generic-entry uncertainty beyond 2031.
  • Ringaskiddy and Catania cuts show manufacturing contraction, signaling more restructuring through 2029.

What makes Pfizer unique

  • Seagen gives Pfizer leading ADCs: Padcev, Tivdak, Adcetris, Tucysa across oncology.
  • Pfizer still owns COMIRNATY distribution scale, with XFG vaccine approved August 27, 2026.
  • Vyndamax settlement extends U.S. exclusivity to June 1, 2031, stabilizing cardiomyopathy cash flows.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

401(k) Retirement Plan

401(k) Company Match

Paid Vacation

Paid Sick Leave

Paid Holidays

Hybrid Work Options

Relocation Assistance

Growth & Insights and Company News

Headcount

6 month growth

-5%

1 year growth

-5%

2 year growth

-5%
Yahoo Finance
Sep 10th, 2026
Medicus Pharma secures Pfizer ADC deal with $2M funding, advances SkinJect for rare cancer treatment

Medicus Pharma has secured a development and licensing agreement with Pfizer for a CD228-targeted antibody-drug conjugate programme focused on solid tumours, including refractory melanoma. Pfizer is providing approximately $2 million in development funding, plus inventory and infrastructure support. CEO Dr Raza Bokhari said the deal allows Medicus to continue from where Pfizer concluded its Phase 1 dose-escalation work, strengthening the company's position in precision oncology. Medicus is also advancing its SkinJect programme for basal cell carcinoma. Final clinical trial results identified the 200-microgram patch as the optimal dose for future studies. The company is preparing for the FDA-approved pivotal SkinJect 005 study whilst recruiting patients. An independent reimbursement analysis suggests SkinJect could achieve reimbursement levels of $25,000 or more per patient.

Yahoo Finance
Sep 8th, 2026
AbbVie beats Pfizer as top dividend stock with 53-year payout streak and 203% growth

AbbVie offers a smarter long-term dividend investment than Pfizer, despite Pfizer's higher 6.1% yield. AbbVie holds Dividend King status with 53 consecutive years of dividend increases and raised its payout by 5.5% this year to $1.73 per share. Over the past decade, AbbVie increased its dividend by more than 203% compared to Pfizer's 51%. AbbVie's revenue grew 138% during this period, whilst Pfizer's rose just 18%. AbbVie successfully navigated Humira's patent cliff through home-grown immunology drugs Skyrizi and Rinvoq. By 2025, these two drugs generated combined annual sales exceeding $25 billion, replacing Humira's peak revenue and pushing total company revenue to record highs. AbbVie's free-cash-flow dividend payout ratio stands at 65%, lower than Pfizer's 89%.

Yahoo Finance
Aug 28th, 2026
Pfizer's updated COVID vaccine ships as FDA approves narrower rollout for over-65s and high-risk groups

Pfizer received FDA approval for its updated Comirnaty COVID-19 vaccine on Thursday, with deliveries to pharmacies and clinics beginning immediately. The company's shares were trading at $27.9079 on 28 August. However, the market opportunity has significantly narrowed from pandemic levels. Eligibility is now limited to adults aged 65 and older, plus higher-risk patients aged 5 through 64. Despite Comirnaty having distributed over five billion doses worldwide historically, today's revenue potential is considerably more constrained. Pfizer faces competition from Moderna and the Novavax-Sanofi protein vaccine for this smaller patient pool. The company's current share price sits 5.27% above its estimated value of $26.51, suggesting investors are paying a premium before actual uptake and commercial results become clear.

Associated Press
Aug 27th, 2026
FDA approves Pfizer-BioNTech XFG-adapted COVID-19 vaccine for high-risk groups

Pfizer and BioNTech have received US Food and Drug Administration (FDA) approval for their 2026-2027 COVID-19 vaccine targeting the XFG variant. The vaccine is approved for adults aged 65 and older, and individuals aged 5 to 64 with underlying conditions that increase risk of severe COVID-19 outcomes. The FDA approval is based on clinical, non-clinical and real-world data demonstrating the vaccine generates strong immune responses against currently circulating SARS-CoV-2 variants, including XFG and other contemporary lineages. The XFG variant was selected following FDA guidance for fall 2026 vaccine composition. The vaccine will begin shipping immediately and will be available in US pharmacies, hospitals and clinics within days. To date, more than five billion doses of COMIRNATY have been distributed globally.

Yahoo Finance
Aug 24th, 2026
Pfizer and J&J navigate patent cliffs with newer drugs offsetting blockbuster losses

Pfizer and Johnson & Johnson are navigating patent cliffs as key drugs lose exclusivity, with their latest results showing differing stages of transition. Pfizer's revenue excluding COVID products grew 5% operationally in Q2 2026, with newer medicines like Padcev and Vyndaqel contributing. The company expects $9.7 billion in cost savings through 2029 to support margins during the transition. Johnson & Johnson's Innovative Medicine sales rose 7.8%, despite Stelara revenue declining 55%. Tremfya sales surged 72.5% to $2 billion, helping offset losses alongside growth from oncology and neuroscience products. Johnson & Johnson raised 2026 guidance, with reported sales expected to reach $101.1 billion and adjusted EPS of $11.68. Its MedTech division provides additional diversification that pure pharmaceutical company Pfizer lacks, suggesting Johnson & Johnson's transition is more advanced.