Senior Scientist/ Scientist
Translational Medicine
Confirmed live in the last 24 hours
Belmont, MA, USA
Experience Level
Desired Skills
Data Analysis
  • PhD and postdoc in Oncology/Cellular and Molecular Biology/Pharmacology or related discipline with 2 years of industry experience (preferred), or Masters with 5+ years of industry experience or Bachelors plus 7+ years in drug discovery and/or translational medicine required
  • Motivated, self-starter, goal-driven, open-minded, creative, collaborative with cross functional skills
  • Strong written & verbal communication skills for presenting data and ideas to multiple stakeholders across disciplines
  • Implementation translational research studies and clinical biomarker assays utilizing cutting-edge technologies
  • Hands-on experience with and expert understanding of molecular and cellular techniques, such as PCR, IHC/IF, digital pathology flow cytometry, NGS assays and their application in clinical trials
  • Ability to design, execute and interpret experiments and communicate experimental results
  • Track record of working effectively with CROs to design and execute studies
  • Experience in validating clinical sites or central labs for implementation of clinical assays preferred
  • Working with the Translational Lead for any given program, the candidate will leverage subject matter expertise in Oncology and mechanistic understanding of disease biology to support translational medicine strategy; development and testing of robust biomarker hypotheses working cross functionally, for one or more assets spanning preclinical to early clinical development programs
  • Support discovery & integration of novel mechanistic, pharmacodynamic, predictive, patient selection biomarkers into trial designs to enable clinical proof of mechanism (POM), proof of biology (POB) endpoints
  • Evaluate new biomarker platforms, develop and validate biomarker assays at outsourced partner laboratories using multiple assay technology platforms (e.g., cell-based assays, molecular assays, single or multiplexed immunoassays, flow cytometry, digital pathology and working knowledge of image analysis; background in IHC/mIF/ histopathological data analyses is a plus)
  • Partnering with TMED and Clinical Operations colleagues, enable seamless implementation of biomarker assays in the clinic
  • Support experimental medicine studies as needed, coordinating and organizing reverse translational plans with access to relevant patient samples
  • Helps review translational medicine-related documentation, including clinical protocols, lab manuals, study reports, abstracts and/or manuscripts and regulatory documents (e.g. IND, IB etc.)
Kymera Therapeutics

51-200 employees