Primary Responsibilities:

• Work independently, collaboratively and cross-functionally to perform analytical development in the separation sciences.
• Develop and execute analytical separation methods that include high-performance liquid chromatography, ultra-performance liquid chromatography and capillary electrophoresis, with focus on mixtures and using appropriate tools.
• Engage in separation theory and separation assay development regarding large biomolecules and small molecules with particular focus on oligonucleotides, lipids, proteins and related molecules.
• Use detectors, biophysical methods, and perform mass spectrometry-based analytical techniques for data analysis (using appropriate tools).
• Design, develop, run and troubleshoot analytical separation assays.
• Troubleshoot and maintain instrumentation that specifically includes evaporative light-scattering detectors, single/quadrupole mass spectrometers, liquid chromatographic systems, and fraction collectors.
• Produce reagents; develop and transfer assays working with external partners.
• Otherwise interact with third-party stakeholders.
• Develop and optimize new scientific processes and scientific method protocols, to include Standard Operating Procedures, both general and specific to assays.
• Write technical and scientific development reports, including regarding assays, while also communicating scientifically-rigorous findings verbally (to include giving presentations, both internally and to third-parties) and by way of visualizations as well.
• Perform biochemical testing.
• Generate, analyze and document research findings and experimental results.
• Analyze biochemical data.
• Provide research support to more senior Beam personnel.
• Continually review new scientific literature.
• Work with co-op student(s)/intern(s) at and rotating through Beam.
• Thaw and grow cell lines, learn and establish new cell lines as needed, maintain the Cell Bank inventory, and fulfill cell line requests.

Qualifications:

• Doctor of Philosophy (“PhD”) or foreign equivalent in biochemistry, chemistry, pharmaceutical sciences, biotechnology, or related field.
• Demonstrated proficiency in all of the following areas, shown through appropriate, graduate-level coursework or classes, or via mandatory, graduate-level laboratory exercises (to include PhD-level dissertation research, for fulfillment of laboratory course requirements, or thesis work as part of graduate program):

• Demonstrated proficiency developing and applying analytical separation methods and techniques, using liquid chromatography and mass spectrometry in particular.
• Regarding experimentation, characterization and analysis involving large biomolecules that include proteins, peptides and nucleic acids.
• Demonstrated proficiency with biochemical pathways and separation and analytical assay development.

Other Information:

• Permanent, full-time, immediately available, job opportunities.
• Do not require travel (as roles are substantially laboratory-based, in-house).
• Must live in the City of Cambridge, MA, or within a reasonable, daily commuting distance thereof (e.g., areas contemplated can include the City of Boston, the larger Greater Boston region, or Massachusetts’ MetroWest, North or South Shore communities).
• Telecommuting (exclusively working remotely from home), it is not permitted (also due to the laboratory-based nature of the work and roles).