Scientist II
Formulation & Biophysical Characterization
Posted on 8/24/2023

201-500 employees

Vaccine innovation company
San Carlos, CA, USA
Experience Level
Biology & Biotech
  • BSc or MSc in Pharmaceutics, Chemistry, Biophysics or Biochemistry preferred, with >4 years of industrial experience; or PhD in Pharmaceutics, Chemistry, Biophysics or Biochemistry with >2 years of relevant experience
  • Experience with biophysical and calorimetric methodologies such as Circular Dichroism, Fourier Transformed Infrared (FTIR) Spectroscopy, Fluorescence Spectroscopy, Differential Scanning Calorimetry (DSC) and Isothermal titration calorimetry (ITC)
  • The candidate should have experience in designing and executing experiments to evaluate the thermal stability of vaccine formulations, including conducting forced degradation and stability studies. Additionally, the candidate should have experience in the use of statistical analysis and Design of Experiments (DoE) for complex system optimization
  • Experience in particle characterization methodologies, such as dynamic light scattering, laser diffraction, microflow imaging, quantitative subvisible particle analysis, visible analysis, would be a distinct advantage
  • Experience in developing proteins, polysaccharides and/or protein conjugates formulations for vaccines, preferably vaccine systems containing adjuvants (other biological experience also considered) would be a plus
  • Strong scientific leadership is required: critical thinking, ability to present complex data sets and to independently propose and design follow-up experiments
  • The candidate should have high degrees of both flexibility and organizational skills as well as an eagerness and ability to learn in order to effectively navigate Vaxcyte's multiple projects and timelines
  • Strong interpersonal skills; ability to communicate effectively both verbally and in written formats (must be able to work with managerial and lab team in remote setting when needed) are necessary to collaborate effectively with the rest of the Formulation and Drug Product Development team and well as across other teams
  • Detail oriented, rigorous and excellent skills in record keeping/documentation
  • All Vaxcyte employees require vaccination against COVID-19
  • Develop biophysical and calorimetric techniques to fully understand antigen conformational stability, antigen/adjuvant interactions and to assess the impact of stress conditions such as thermal, mechanical and freezing on the stability of vaccine antigens
  • Support formulation development activities, including stability studies for thermal, freeze/thaw, and agitation as well as container closure system evaluation for both Drug Substance (DS) and Drug Product (DP) materials
  • Work with external analytical and manufacturing CMOs to enable tech transfer and implementation of processes and analytical methods