Manufacturing Associate @ Orca Bio

INACTIVE

Full-Time

Manufacturing Associate

Posted on 3/31/2023

Orca Bio

51-200 employees

Clinical-stage cell therapy company

Biotechnology

Junior, Mid

Sacramento, CA, USA

Requirements

Master's or bachelor's degree in biology or related field
1-2 years of experience in process sciences, discovery research or manufacturing
Experience with aseptic techniques
Breadth of knowledge of cell therapy and clinical manufacturing, cell processing technologies, cell characterization methods, validation and quality systems
A background in immunology, oncology or cell therapy
Flow cytometry experience, including sorting and analyzing cells
Experience working with human cells
GMP experience and/or eagerness to learn the manufacturing process under GMP

Responsibilities

Faithfully execute scientific protocols
Develop cell therapy for blood diseases
Optimize cell assays
Use cell separation technologies
Perform flow cytometry and analyze data
Work with new technology
Review and support continuous improvements of records and SOPs
Analyze results, maintain detailed records of experiments and outcomes
Participate in group research discussions
Prepare, maintain, trouble-shoot, and operate instruments
Participate in group research discussions
Highly detail-oriented, and pays special attention to quality and quality control
A multi-tasker who can handle and prioritize multiple responsibilities simultaneously
Curious to learn and eager to step-up immediately in a fast-paced, collaborative start-up environment
Able to work both independently and as part of a team, and seamlessly transition between the two
Strong problem-solving skills with the desire to improve upon established processes
Eager to onboard, train, and mentor new team members

Over one million people in the world today are fighting blood cancer. While a traditional allogeneic stem cell transplant has been the best hope for many patients, the transplant itself can prove fatal or lead to serious conditions, such as graft versus host disease.

Orca Bio’s investigational, high-precision cell therapies are designed to replace a patient’s compromised blood and immune system with a healthy one, while dramatically lowering the risk of developing life-threatening or debilitating transplant-related side-effects. The first application of Orca Bio’s platform is in blood cancer where the unmet need is most acute; with a robust pipeline of promising cell therapies, we plan to extend into autoimmune diseases and genetic blood disorders as well.

Why this role is important

Having in-house cGMP manufacturing capacity is a critical part of Orca’s road-map. The Manufacturing Research Associate helps optimize processes and conducts cGMP manufacturing activities to produce our cell therapies in support of clinical studies, which in turn allow us to secure FDA approval, scale, and serve more patients.

Because manufacturing for clinical studies requires significant coordination with hospital sites, donors, and patients, we need dedicated team members who understand that timing is everything - we literally hold patient cells in our hands. If you’re willing and eager to roll-up your sleeves and work on a flexible schedule (including occasional graveyard shifts to process cells) in a BSL-2 environment, you’re meant to be on our team!

What you’ll do

Faithfully execute scientific protocols
Develop cell therapy for blood diseases
Optimize cell assays
Use cell separation technologies
Perform flow cytometry and analyze data
Work with new technology
Review and support continuous improvements of records and SOPs
Analyze results, maintain detailed records of experiments and outcomes
Participate in group research discussions
Prepare, maintain, trouble-shoot, and operate instruments
Participate in group research discussions

What prior experience you have

Master’s or bachelor’s degree in biology or related field
1-2 years of experience in process sciences, discovery research or manufacturing
Experience with aseptic techniques
Breadth of knowledge of cell therapy and clinical manufacturing, cell processing technologies, cell characterization methods, validation and quality systems

What other experiences would help

A background in immunology, oncology or cell therapy
Flow cytometry experience, including sorting and analyzing cells
Experience working with human cells
GMP experience and/or eagerness to learn the manufacturing process under GMP

You will excel if you are...

Highly detail-oriented, and pays special attention to quality and quality control
A multi-tasker who can handle and prioritize multiple responsibilities simultaneously
Curious to learn and eager to step-up immediately in a fast-paced, collaborative start-up environment
Able to work both independently and as part of a team, and seamlessly transition between the two
Strong problem-solving skills with the desire to improve upon established processes
Eager to onboard, train, and mentor new team members

Who we are

We are scientists, engineers and business operators working with urgency to develop new therapies for patients faced with no or extremely limited options today.

We are driven by a passion for science and compassion for patients. We act with urgency to ensure our treatments are one day accessible to all patients who need them.

We strive to do things right. Excellence in our work means the potential to unlock a better quality of life for our patients, and with that comes tremendous responsibility.

We innovate daily on a path that hasn’t been paved. This means we lean heavily on our entrepreneurial spirit and are comfortable taking calculated risks to achieve progress toward our mission. It means we aren’t afraid to ask “why not”, and encourage lively discourse around rethinking the status quo.

We work hard to preserve our start-up culture rooted in camaraderie and leadership by example - by everyone, regardless of title.

We’re proud to be an equal opportunity employer, and have seen how our differences - when celebrated and woven together - create stronger and more lasting solutions that better serve our team, our partners, and most importantly, our patients and the providers who treat them.

We invite you to join us and bring your unique perspective and experiences to our team.

Orca Bio

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Website

View Company Profile

Abata's mission is to translate the biology of regulatory T cells (Tregs) into transformational medicines for patients with progressive multiple sclerosis and other serious autoimmune and inflammatory diseases. Abata is bringing an entirely new approach to the treatment of autoimmune disease by engineering Tregs as targeted therapies that stop immune-mediated destruction, restore homeostasis – a state of harmony – and promote repair in the affected tissues.

Company Stage

Series D

Total Funding

$375M

Headquarters

Menlo Park, California

Founded

2016

Growth & Insights

Headcount

6 month growth

↑ 4%

1 year growth

↑ 24%

2 year growth

↑ 38%

INACTIVE