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Full-Time

Senior Associate Scientist

Confirmed live in the last 24 hours

Fractyl Health, Inc

Fractyl Health, Inc

51-200 employees

Therapies for Type 2 Diabetes

Healthcare
Biotechnology

Mid, Senior

Burlington, MA, USA

Category
Genomics
Biology Lab & Research
Biology & Biotech
Requirements
  • Bachelor’s or Master’s in Biology or related discipline
  • Bachelor’s with at least 5 years relevant hands-on work experience or a Master’s with at least 2 years post graduate relevant hands-on work experience
  • Proficiency in all stages of Molecular plasmid cloning techniques
  • Oligo and plasmid design using software (e.g., SnapGene, Benchling)
  • PCR amplification, gel electrophoresis and analysis
  • DNA restriction and ligation (e.g., restriction enzymes, Golden Gate, Gibson)
  • Bacterial transformation, plating, culturing, DNA prep, and colony screening
  • Submission of samples for Sanger sequencing and sequencing analysis
  • Experience in DNA, RNA, and protein isolation from cells and/or tissue samples
  • Experience in nucleic acids handling, quantitation, and analysis (e.g. Nanodrop, Qubit, Bioanalyzer qPCR, ddPCR, RT, etc.)
  • Experience in protein analysis (e.g., ELISA, Western blot, Jess, etc.)
  • Experience in cell-based assays (e.g. flow cytometry, luminescence assays, etc)
  • Experience in cell culture work (e.g., maintenance, transfection, transduction)
  • Experience in AAV production (Preferred)
  • Experience with electronic lab notebook documentation (Preferred)
Responsibilities
  • Clone transgene constructs, generating sequence-verified plasmid DNA
  • Maintain and culture cells (e.g., HEK293, immortalized endocrine cells, primary cells)
  • Screen transgene construct expression and performance in transfected/transduced cells
  • Development and application of molecular and cell-based assays (e.g., gel electrophoresis, PCR, qPCR, ddPCR, ELISA, western blot/Jess, flow cytometry, MSD)
  • Assist in AAV production, purification, and QC as needed
  • Apply molecular/biochemical assays to *ex vivo* and *in vivo* studies as needed
  • Analyze experimental data, generating plots and summarizing results and conclusions
  • Maintain a comprehensive Electronic Lab Notebook documenting experiments
  • Perform all activities in compliance with applicable regulations, Fractyl’s policies and guidelines, including all required applicable training
  • Bring a "can do" spirit to work and deliver on other responsibilities as assigned

Fractyl Health focuses on creating therapies for Type 2 Diabetes (T2D) and obesity, targeting the root causes of these metabolic diseases. Their main product, Rejuva, is a gene therapy platform aimed at improving the function of pancreatic islet cells, which are essential for blood sugar regulation. By enhancing these cells, Fractyl hopes to achieve long-term remission for patients with T2D and obesity. Currently, Rejuva is in preclinical development and has received a CE mark for commercial availability in Europe, although it is still awaiting full FDA approval. Unlike many competitors, Fractyl's approach centers on gene therapy to address the underlying issues of these diseases rather than just managing symptoms. The company's goal is to transform the treatment landscape for T2D and obesity, ultimately preventing and eliminating these conditions.

Company Stage

IPO

Total Funding

$395.4M

Headquarters

Lexington, Kentucky

Founded

2010

Growth & Insights
Headcount

6 month growth

6%

1 year growth

17%

2 year growth

14%
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Simplify's Take

What believers are saying

  • Fractyl's innovative approach to metabolic diseases could revolutionize treatment paradigms, offering significant career growth opportunities in a pioneering field.
  • The appointment of experienced leaders like Adrian Kimber and Dr. Timothy Kieffer strengthens the company's strategic and scientific capabilities, enhancing its market positioning.
  • Successful IPO and promising preclinical results for Rejuva indicate strong financial backing and potential for substantial market impact.

What critics are saying

  • The success of Fractyl Health is heavily dependent on the regulatory approval and commercial adoption of its therapies, which are still in preclinical or early clinical stages.
  • The competitive landscape for diabetes and obesity treatments is intense, with numerous established players and emerging startups vying for market share.

What makes Fractyl Health, Inc unique

  • Fractyl Health focuses on gene therapy for Type 2 Diabetes and obesity, targeting the root causes of these diseases, unlike many competitors who focus on symptom management.
  • Their flagship product, Rejuva, aims to enhance pancreatic islet cell function, offering a potential long-term remission solution for T2D and obesity.
  • The company has achieved a CE mark for Rejuva, indicating compliance with stringent health and safety standards in the European Economic Area, setting it apart from competitors still in investigational stages.