Senior Research Associate

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity
Praxis is looking for a talented Senior Research Associate to be a key member of the Formulation and Manufacturing Process Development group within the Technical Operations/CMC team.  You will be responsible for the formulation and manufacturing process development for oral dosage forms for small molecules and parenteral dosage forms for antisense oligonucleotides (ASOs).  You will participate in the design and oversee the execution of pre-formulation, formulation, and manufacturing process development studies at contract development and manufacturing organizations (CDMOs).  You’ll also process,analyze, and present experimental data, along with writing and reviewing technical reports.

Primary Responsibilities

• Participate in the design and oversee the execution of formulation development studies for small molecule and ASOs at CDMOs. 
• Participate in the design and oversee the execution of oral solid and liquid dosage forms manufacturing process development, process scale-up, technology transfer to and between CDMOs and oversee clinical manufacturing campaigns at CDMOs.  Manufacturing processes involvement but not limited to granulation, encapsulation, tableting, coating, and spray drying. 
• Participate in the design and oversee the execution of pre-formulation studies to characterize solubility, ionization constant, lipophilicity, chemical stability, and-solid state properties of drug candidates.  Testing includes but not limited to pharmaceutical powder characterization, pH measurement, HPLC, TGA, DSC, microscopy, dissolution, and XRPD.
• Work effectively with CDMOs to ensure that Praxis’s formulation development and clinical manufacturing needs are met. 
• The incumbent will be responsible for compiling and organizing data, preparing summary presentations, and authoring technical reports. Effective communication skills are desirable for interaction with internal and external stakeholders in a highly interdisciplinary and collaborative research and development environment

Qualifications and Key Success Factors

• BS or MS in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
• 5+ years of relevant experience in formulation development in an industry setting.
• Familiarity with physicochemical characterization techniques and formulation principles.
• Excellent organizational, documentation, and communication skills.
• Demonstrated curiosity, ownership, and collaborative mindset.
• The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.  You'll need comfort with screen work, basic hand coordination, and focus.  Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! 

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  Final salary range may be modified commensurate with job level, education, and experience.