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Senior Scientist/Scientist II
Structural Biology
Confirmed live in the last 24 hours
Belmont, MA, USA
Experience Level
  • PhD in Structural Biology or related discipline
  • Experience working with CROs is preferred
  • Extensive knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, crystallization, structure determination and analysis
  • Experience in single particle cryo-EM workflow including grid freezing and screening, data collection and processing, three-dimensional reconstruction and model building
  • Excellent presentation skills (written and oral) that enhance team-based delivery of results
  • Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment
  • Skills in managing multiple projects and capability to prioritize
  • As a member of the protein sciences and lead discovery team, lead protein sciences and structural biology efforts to identify, validate, and fully characterize small molecule ligands and progress to targeted protein degraders
  • Contribute to the strategy for bringing novel E3 ligase and oncology/immunology targets to the Kymera portfolio
  • In collaboration with chemistry, biology, and platform teams, characterize binary and ternary complex formation and establish SAR to rapidly drive the hit finding, hit-to-lead, and lead optimization process
  • Deliver data, contribute to critical data evaluation, and provide strong discipline leadership to project teams
  • Augment our toolbox of structural biology techniques to address the specific needs of targeted protein degradation drug discovery
Desired Qualifications
  • 1-3 years of biotech/pharma industry experience with a track record of hit-finding, hit-to-lead, and lead optimization towards delivering small molecule development candidates is a plus
  • General knowledge of signaling pathways, protein homeostasis, and regulation of gene expression in a diverse disease context. Experience in targeted protein degradation or molecular glues is a plus
Kymera Therapeutics

51-200 employees