We are seeking an experienced and motivated structural biologist to join the Protein Sciences and Lead Discovery team at Kymera Therapeutics.  As part of a dynamic team, the successful candidate will provide critical structural support (both x-ray crystallography and cryo-electron microscopy) for the identification and optimization of ligands to novel and proprietary E3 ligases as well as “undruggable” proteins of interest and will both conduct internal and drive external experiments to advance projects toward their goals. Kymera is advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade rather than inhibit dysregulated, disease-causing proteins. This position will also play an important role in the progression of these binders to degraders. The successful candidate will work in a fast-paced and highly matrixed discovery environment requiring scientific rigor, organized and independently driven work, and exceptional attention to detail. 

Kymera Therapeutics is a publicly listed, clinical stage biotechnology company pioneering the field of targeted protein degradation (TPD) to bring life-changing medicines to patients that need them. Kymera’s Pegasus™ TPD platform harnesses the body’s natural protein recycling machinery to degrade disease-causing proteins, with a focus on undrugged nodes in validated pathways currently inaccessible with conventional therapeutics. As we work toward becoming a fully-integrated biopharmaceutical company, we are growing and strengthening organizational capabilities and evolving our culture. As a result, Kymera has been recognized by both the Boston Globe and the Boston Business Journal as one of Boston’s top workplaces.

In 2023, we plan to continue to advance our leadership in TPD and enhance our capabilities to deliver on the potential of inventing a new class of protein degrader medicines for patients. Kymera is rapidly advancing four clinical stage programs in oncology and immunology, and is positioned to deliver one additional Investigational New Drug Applications (IND) annually. We are also actively advancing a broad pipeline of preclinical programs where TPD has the potential to provide a best-in-class approach, both internally and in collaboration with our partners Sanofi and Vertex Pharmaceuticals.

Responsibilities:

• As a member of the protein sciences and lead discovery team, lead protein sciences and structural biology efforts to identify, validate, and fully characterize small molecule ligands and progress to targeted protein degraders.
• Contribute to the strategy for bringing novel E3 ligase and oncology/immunology targets to the Kymera portfolio.
• In collaboration with chemistry, biology, and platform teams, characterize binary and ternary complex formation and establish SAR to rapidly drive the hit finding, hit-to-lead, and lead optimization process.
• Deliver data, contribute to critical data evaluation, and provide strong discipline leadership to project teams.
• Augment our toolbox of structural biology techniques to address the specific needs of targeted protein degradation drug discovery.

Qualifications:

• PhD in Structural Biology or related discipline.
• 1-3 years of biotech/pharma industry experience with a track record of hit-finding, hit-to-lead, and lead optimization towards delivering small molecule development candidates is a plus.
• Experience working with CROs is preferred.
• Extensive knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, crystallization, structure determination and analysis.
• Experience in single particle cryo-EM workflow including grid freezing and screening, data collection and processing, three-dimensional reconstruction and model building.
• General knowledge of signaling pathways, protein homeostasis, and regulation of gene expression in a diverse disease context. Experience in targeted protein degradation or molecular glues is a plus. 
• Excellent presentation skills (written and oral) that enhance team-based delivery of results.
• Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment.
• Skills in managing multiple projects and capability to prioritize.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.