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Job Description
The Protein Therapeutics Department in Gilead is looking for an Associate Scientist with protein purification and biochemistry expertise. The candidate will join the growing Protein Biochemistry group to deliver high-quality recombinant proteins to enable small-molecule and large-molecule drug discovery campaigns.
The scientist will be a key contributor to project teams focused on new therapies in Immunology, Oncology, and Virology. The primary role will be to express and purify recombinant forms of intracellular and extracellular target proteins and characterize their properties with guidance from senior staff members. The scientist will analyze and interpret the data to trouble shoot and optimize the expression/purification procedures to meet the QC requirements. The candidate will have the opportunity to interact closely and collaborate across all functions of Drug Discovery—Biology, Biologics Discovery, Structural and Computational Biology, and Biophysical and Biochemical Assay.
The position will require the scientist to work creatively, collaboratively, and in a fast-paced environment. He/she will also be encouraged to test and implement new technologies that further enhance the capabilities of the Protein Biochemistry team or address challenges in protein generation.
Education and Technical Skills:
MS with 3+ years OR BS with 5+ years of industry experience in a related scientific discipline, such as protein biochemistry and structural biology.
Hands-on experience of expressing and purifying quality proteins from bacterial and/or insect cells is required.
Training in classical protein purification processes and techniques (affinity, ion exchange, size exclusion chromatography using AKTA chromatographic instruments) as well as knowledge of protein analytical tools (SDS-PAGE analysis, Western blot, HPLC, DLS, DSF, Mass Spectrometry) is required.
Excellent communication and interpersonal skills; works independently and as a team player.
Attention to detail, accurate record keeping, and good lab citizenship practices are essential.
Prior experience with membrane protein purification and characterization is a plus but not required.
Prior experience with high-throughput protein expression and purification is a plus but not required.
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For Current Gilead Employees and Contractors:
Please log onto your Internal Career Site to apply for this job.
