Position Overview:

We are currently seeking a motivated and accomplished Engineer I/Engineer II to join the Automated Assays and Operations team in Prime’s growing Technical Development and Operations Organization. This individual will focus on developing and automating plate-based analytical assays, including ELISA and cell-based assays, for the characterization, stability, and release testing of critical reagents, drug substance (DS), and drug product (DP). This role is hands-on and a successful candidate will be involved in automated system design, integration, programming, implementation, and maintenance as well as assay development and qualification. This role interfaces will all parts of the company from early discovery to QC testing, and therefore the ideal candidate will work well in a matrixed environment.

This is a hands-on role where the successful candidate will be involved in day-to-day activities in assay development supporting programs in development and discovery stage. The ideal candidate will excel in a matrixed environment, as this role will interface with the process development, pharmacology, formulation, biology, and quality teams to advance Prime’s prime editing pipeline. Our ideal candidate is a creative problem solver with the energy to drive an ambitious assay development, automation and operations agenda, which support Prime’s development programs’ goals.

Key Responsibilities:

• Design, integrate, and program automation systems
• Design, develop, and automate plate-based (ELISA, Cell-based, mix and read) assays
• Run and qualify assays
• Integrate workflows with ELN and LIMS to support scalability and flexibility.
• Identify bottlenecks impeding the team, and proactively implement solutions.
• Work with scientists to understand current workflows, assay design, and automation needs
• Identify metrics to be collected from workflows, and creation of system for metrics collection, visualization, and reporting in order to identify improvement areas
• Continually look for new or improved technologies to evaluate for increasing capacity or optimization
• Work with instrument vendors and external contractors to evaluate, design, and implement new solutions.

Qualifications/Requirements

• BS + 5 years/MS + 3 years in Biology or Engineering disciplines.
• Experience in plate-based assay development, with emphasis on mix-and-read, ELISA, and cell-based assays
• Experience in lab automation, including liquid handlers (Tecan, Hamilton, Dynamic Devices, etc), scheduling software (Cellario, Genera, Green Button Go), and robotic arms (Precise, KX-2)
• Programming proficiency (.NET, C++, C#, python, java)
• Strong collaborator with cross-functional teams and external partners
• Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
• Highly self-motivated, driven, can-do, make it happen attitude with ability to own and drive projects
• Capable of continuous learning, open-minded, curious, highly organized, and detail-oriented