Engineer II/Senior Engineer
Manufacturing Sciences & Technology
Posted on 1/17/2023
INACTIVE
Beam Therapeutics

201-500 employees

Pioneering precision genetic medicines through CRISPR base editing
Company Overview
Beam Therapeutics, established in 2018, is a pioneer in the field of genetic medicine, utilizing CRISPR base editing to create precise, permanent alterations to single bases in DNA and RNA without breaking the strands. The company's culture is characterized by a community of fearless innovators, rigorous and honest research, open-mindedness, and commitment to each other. Their competitive advantage lies in their unique delivery strategy, which includes a range of clinically validated technologies such as electroporation, nonviral, and viral delivery modalities, positioning them as a leader in the genetic medicine industry.
Biotechnology

Company Stage

N/A

Total Funding

$689M

Founded

2017

Headquarters

Cambridge, Massachusetts

Growth & Insights
Headcount

6 month growth

-10%

1 year growth

-10%

2 year growth

32%
Locations
Research Triangle, Durham, NC, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Requirements
  • Ph.D. in Chemical Engineering, Bioengineering, Biochemistry, or equivalent with minimum 2-6 years of relevant work experience, or a M.S. degree with a minimum of 4-8 years of relevant work experience, or a B.S. degree with a minimum 6-10 years of relevant work experience
  • Level will be commensurate with experience and academic background
  • Demonstrated technical expertise within downstream processing for production of large molecule biologics, gene, mRNA and/or LNP therapeutics (experience in mRNA/LNP production is preferred)
  • Demonstrated experience in technology transfer and implementation of complex biologics processes
  • Prior hands-on purification development experience preferred
  • Strong background in drug development and regulatory requirements, fluency in process validation lifecycle requirements
  • Experience successfully leading manufacturing event investigations, Root Cause Analysis (RCA), and CAPA
  • Outstanding written and verbal written communication skills, with the ability to convey strategies and results to a diverse audience
  • Dynamic interpersonal skills and the ability to manage through influence
  • Ability to juggle multiple projects and priorities and adapt quickly to changing circumstances
  • High degree of customer focus (internal/external) and demonstrated collaboration in a team environment
  • Results oriented with the ability to demonstrate resiliency, ownership and drive
Responsibilities
  • Leads or supports the technology transfer and implementation of mRNA/LNP programs, collaborates with sending and receiving site cross-functional team members
  • Leads or contributes to the establishment of technical documentation including tech transfer plans, facility fit and gap analysis reports, manufacturing study protocols and reports, standard operating procedures, process validation master plans/protocols/report, risk assessments, etc
  • Supports facility and equipment design and qualification to meet process and regulatory expectations
  • Establishes technical documentation including tech transfer planes, investigations, manufacturing study protocols and data analysis to support deviations and change controls
  • Supports regulatory submissions and responses, audits and regulatory inspections, as required
  • Represents the MS&T team within cross functional project teams related to the mRNA/LNP programs
  • Leads and/or assists with manufacturing deviation investigations and change controls
  • Provides Person-In-Plant (PIP) support to manufacturing, as required
  • Establishes and maintains strong relationships at the site and cross-functionally
  • Travel is expected to be up to 10% of time for in-person interactions with cross-functional partners and trainings
  • Must be willing to have a flexible schedule during initial site start up, which may include supporting critical operations outside of normal work hours, as needed
  • Must be able to work onsite