Senior Viral Vector Bioprocess Engineer @ Asimov

INACTIVE

Full-Time

Senior Viral Vector Bioprocess Engineer

Posted on 1/12/2023

Asimov

51-200 employees

Provides tools for designing and manufacturing biological cells

Biotechnology

Senior

Dorchester, Boston, MA, USA

Requirements

6+ years experience in upstream process development at a biopharma company or CDMO
Bachelor's or Master's degree in Chemical Engineering, Bioengineering, Biotechnology, or a related field. PhD is preferred but not required
Experience scaling-up an upstream mammalian cell culture process from benchtop to pilot or production-scale manufacturing
Deep mammalian cell culture expertise in AAV or lentivirus production
Experience working with shake flasks and small-scale automated bioreactors (e.g., AMBR15) in industry
Knowledge of regulatory filing requirements
Mastery of bioreactor operations including fed-batch and perfusion modes
Experience with statistical tools/DOE for experimental design or process optimization
Strong written and verbal communication skills

Responsibilities

Spearhead the roadmapping and development of mammalian bioreactor and upstream process infrastructure
Design and execute bioreactor and shake flasks experiments to develop mammalian cell culture processes for production of viral vectors
Lead upstream process scale-up with commercial partners
Be a technical resource within the Synthetic Biology team by mentoring junior peers and adjacent technical roles
Collaborate with the Automation and Software teams to develop automated systems for coordinating bioreactor runs and integrating process data into our computational platform
Communicate ideas, data, and strategy with other technical members, executives, and commercial partners
Organize and document experiments and data in an electronic lab notebook

Our mission at Asimov is to advance humanity’s ability to design living systems, enabling biotechnologies with outsized benefit to society. We’re developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

We are seeking a Senior Viral Vector Bioprocess Engineer who is excited about pushing the state-of-the-art in viral vector production. You will be responsible for designing, executing, and optimizing mammalian cell culture processes using bench-top bioreactors, with the goal of developing scalable and robust processes for production of lentivirus and AAV. By working closely with the Synthetic Biology team, you will play a key role in developing cutting-edge technology for advanced manufacturing of next-generation therapeutics. You will also interface with pilot scale and commercial production facilities to ensure effective technology transfer and regulatory filings. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup to help build the future of biological engineering.

As an Senior Viral Vector Bioprocess Engineer you will:

Spearhead the roadmapping and development of mammalian bioreactor and upstream process infrastructure
Design and execute bioreactor and shake flasks experiments to develop mammalian cell culture processes for production of viral vectors
Lead upstream process scale-up with commercial partners
Be a technical resource within the Synthetic Biology team by mentoring junior peers and adjacent technical roles
Collaborate with the Automation and Software teams to develop automated systems for coordinating bioreactor runs and integrating process data into our computational platform
Communicate ideas, data, and strategy with other technical members, executives, and commercial partners
Organize and document experiments and data in an electronic lab notebook

About you:

6+ years experience in upstream process development at a biopharma company or CDMO
Bachelor’s or Master’s degree in Chemical Engineering, Bioengineering, Biotechnology, or a related field. PhD is preferred but not required
Experience scaling-up an upstream mammalian cell culture process from benchtop to pilot or production-scale manufacturing
Deep mammalian cell culture expertise in AAV or lentivirus production
Experience working with shake flasks and small-scale automated bioreactors (e.g., AMBR15) in industry
Knowledge of regulatory filing requirements
Mastery of bioreactor operations including fed-batch and perfusion modes
Experience with statistical tools/DOE for experimental design or process optimization
Strong written and verbal communication skills

We’re fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Asimov

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Asimov's unique approach to biotechnology, integrating synthetic biology, computer-aided design, and machine learning, positions it as a leader in the design and manufacture of biologics and gene therapies. The company provides comprehensive support to its clients, offering both the tools for in-house cell line development and a service to create custom cell lines, demonstrating a commitment to flexibility and customer needs. Asimov's culture fosters interdisciplinary collaboration, driving technical advancements and enhancing its competitive edge in the biotech industry.

Company Stage

Series B

Total Funding

$204.7M

Headquarters

Boston, Massachusetts

Founded

2017

Growth & Insights

Headcount

6 month growth

↑ 13%

1 year growth

↑ 35%

2 year growth

↑ 127%

INACTIVE