In Vitro Associate Principal Scientist/Pharmacology

Confirmed live in the last 24 hours

Locations

San Bruno, CA, USA

Experience Level

Entry

Junior

Mid

Senior

Expert

Requirements

PhD + 8+ years (can include postdoc experience), in pharmacology, or related discipline (must have a minimum of 2+ years industry leading early discovery projects to IND, functional lead experience acceptable)
Proficient in experimental biological techniques such as immunoassays (ELISA, MSD, Luminex), qPCR, biochemical assays, enzyme kinetics, Western Blot, RNA extractions, etc
Working knowledge of cell cultures, including mammalian cell culture
Compound screening experience
Developed novel complex model systems (didn't just purchase off the shelf)

Responsibilities

Lead the in-vitro pharmacology team, working across programs to enable characterization and screening of new compounds
Develop and execute in vitro assays to validate compound activity using cell-free and cell-based models
Perform cell cultures and mainteneance of cell lines to be used to evaluate small molecules in high and medium throughput assays
Perform assays to enable chemistry SAR iterations
Screen and test libraries of small molecules in both internal assays and with CROs
Mange CRO relationships to support high-throughput screens
Accurate and organized data entry, analysis, technical report writing, and presentation of experimental results to research groupsIdentification of best model / troubleshooting / leading projects
Select and champion complex, yet robust in vitro model systems for target biology
Manage a direct report to enable high and medium throughput screens to support all drug discovery programs

Desired Qualifications

Experience with neuroscience is a plus
Transcriptomics (RNA extractions, library prep), experience with NGS is a plus

Who We Are:

Technology has transformed the way we work, communicate, travel, eat, move, and more. Yet in biopharma, it still takes 12 years to develop a single drug. Even today, thousands of diseases affecting hundreds of millions of people have no effective treatment. Accelerating the pace of bringing effective, new medicines to patients is one of the greatest opportunities for humanity.

Our mission is to develop better drugs, faster using technology. We have built an end-to-end technology-driven drug discovery platform centered around one of the field’s largest human genomics databases in neuroscience. We use machine learning to map the complex causes of disease and turn those insights into promising drug candidates on our internal biology and chemistry platforms. We are developing drugs to treat some of the biggest medical challenges today: ALS, Parkinson’s Disease, and Alzheimer’s Disease.

We have raised $134M from top tier investors (e.g. BlackRock, Eli Lilly, Merck, Section 32, Threshold Ventures, Y Combinator, etc.). We are a team of engineers, neuroscientists, and drug developers united around an audacious vision: to build the next Genentech of the digital age.

Let’s transform patient lives, together.

You Will:

Lead the in-vitro pharmacology team, working across programs to enable characterization and screening of new compounds.
Develop and execute in vitro assays to validate compound activity using cell-free and cell-based models.
Perform cell cultures and mainteneance of cell lines to be used to evaluate small molecules in high and medium throughput assays.
Perform assays to enable chemistry SAR iterations.
Screen and test libraries of small molecules in both internal assays and with CROs.
Mange CRO relationships to support high-throughput screens.
Accurate and organized data entry, analysis, technical report writing, and presentation of experimental results to research groupsIdentification of best model / troubleshooting / leading projects.
Select and champion complex, yet robust in vitro model systems for target biology.
Manage a direct report to enable high and medium throughput screens to support all drug discovery programs.

You Have"

PhD + 8+ years (can include postdoc experience), in pharmacology, or related discipline (must have a minimum of 2+ years industry leading early discovery projects to IND, functional lead experience acceptable)
Proficient in experimental biological techniques such as immunoassays (ELISA, MSD, Luminex), qPCR, biochemical assays, enzyme kinetics, Western Blot, RNA extractions, etc.
Working knowledge of cell cultures, including mammalian cell culture
Compound screening experience
Experience with neuroscience is a plus
Developed novel complex model systems (didn’t just purchase off the shelf)
Transcriptomics (RNA extractions, library prep), experience with NGS is a plus

Compensation & Benefits at Verge Genomics:

Our target starting salary for successful US-based applicants for this role is $131,500 to $156,500. To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, the level at which they are actually hired, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and all employees are offered Equity, subject to the terms of those plans and associated policies.

In addition, Verge Genomics also provides our employees:

*Excellent medical, dental, and vision coverage

*401(k) plan with employer matching for contributions

*Disability insurance, Life insurance, Dependant Care FSA and Healthcare FSA

*Unlimited paid time off

*Paid parental leave

*Access to free onsite fitness center

*Free snacks and lunch for employees who work onsite

*WFH stipend for employees who work remotely

Help us revolutionize the way drugs are discovered & developed:

The startup nature of Verge Genomics provides multiple growth opportunities into other areas of the company. As one of the early employees at Verge, your work will have a direct impact on the foundation of a groundbreaking new drug development model.

11-50 employees

Website

AI drug discovery biotech company

Company Overview

Verge Genomics is on a mission to develop better drugs, faster using technology. The company has built an end-to-end technology-driven drug discovery platform centered around one of the field’s largest human genomics databases in neuroscience.

Benefits

Excellent medical, dental, and vision coverage
401(k) plan with employer matching for contributions
Disability insurance, Life insurance, Dependant Care FSA and Healthcare FSA
Unlimited paid time off
Paid parental leave
Access to free onsite fitness center
Free snacks and lunch for employees who work onsite
WFH stipend for employees who work remotely

Company Core Values

We commit to embracing courageous ambition
We commit to treating every situation as an opportunity to improve
We commit to revealing our authentic truths (facts, feelings, things I imagine) to each other