You Will:

• Lead the in-vitro pharmacology team, working across programs to enable characterization and screening of new compounds.
• Develop and execute in vitro assays to validate compound activity using cell-free and cell-based models.
• Perform cell cultures and mainteneance of cell lines to be used to evaluate small molecules in high and medium throughput assays.
• Perform assays to enable chemistry SAR iterations.
• Screen and test libraries of small molecules in both internal assays and with CROs.
• Mange CRO relationships to support high-throughput screens.
• Accurate and organized data entry, analysis, technical report writing, and presentation of experimental results to research groupsIdentification of best model / troubleshooting / leading projects.
• Select and champion complex, yet robust in vitro model systems for target biology.
• Manage a direct report to enable high and medium throughput screens to support all drug discovery programs.

You Have"

• PhD + 8+ years (can include postdoc experience), in pharmacology, or related discipline (must have a minimum of 2+ years industry leading early discovery projects to IND, functional lead experience acceptable)
• Proficient in experimental biological techniques such as immunoassays (ELISA, MSD, Luminex), qPCR, biochemical assays, enzyme kinetics, Western Blot, RNA extractions, etc.
• Working knowledge of cell cultures, including mammalian cell culture
• Compound screening experience
• Experience with neuroscience is a plus
• Developed novel complex model systems (didn’t just purchase off the shelf)
• Transcriptomics (RNA extractions, library prep), experience with NGS is a plus