Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.

We are seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for Director/ Senior Director of In Vivo Pharmacology, Preclinical Development to join our team and advance our platform into the IND enabling studies. The candidate should have a passion for working collaboratively with biologists and bioengineers and develop preclinical strategies for the IND enabling studies that will bring gene editing modalities into first-in-human studies.

The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a cross-functional leadership role of increasing responsibilities that spans across the pipeline, and the ability to publish highly impactful work in peer reviewed journals. 

Key Responsibilities:

• Conceptualize, direct and oversee complex in vivo pharmacology, dose ranging, and GLP toxicology IND enabling studies in NHPs.
• Analyze in-life data, functional assessments, and ex vivo biomarker data from IND enabling nonclinical studies.
• Author and finalize study reports for regulatory filings (this work will have a direct impact on the development course of preclinical programs and will be integral for regulatory submissions)
• Cross-functional interface with internal teams, as well as external collaborators and CROs
• Research and propose new preclinical endpoints which can be used to support proof of concept and efficacy biology
• Working closely with the discovery biology team to implement and execute in vivo study designs (for the IND enabling studies)
• Prepare and organize data from preclinical in vivo studies appropriate for presentations 
• Growth mindset (with an intention to learn together and improve through iteration cycles of gene-editing drug development modalities), value transparency and camaraderie  
• Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science

Required Skills and Background:

• Considerable experience in drug development, in vivo (NHP) study design, and scientific reporting writing
• 8+ (B.S.), 5+ (M.S.) or 3+ (Ph.D) years’ experience in drug development and in vivo pharmacology (candidates that directed IND enabling NHP studies at the contract research organizations and willing to gain drug development experience are also encouraged to apply)
• Previous in vivo-pharmacology experience in large mammals and leading interactions with CROs (managing non-GLP and GLP-toxicology NHP studies conducted at the specialty CROs)
• Experience in supervising GLP toxicology studies and determination of first-in-human safety doses
• Previous experience incorporating preclinical in vivo data into regulatory filings
• A history of authoring publications and/or study reports
• Detail oriented, naturally seek ownership and responsibility, and excited and comfortable working in uncharted territory of gene editing
• Comfortable in a fast-paced young biotech environment with a dynamic cross-functional team 
• Direct experience in gene therapy/editing and/or cardiovascular/liver diseases is beneficial but not necessary.
• Familiarity with CRISPR technologies and therapeutic approaches is beneficial but not necessary. 

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to join our team of engineers and carve the future of therapeutics, then we are excited to hear from you! Visit us at www.scribetx.com.  

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status.