Full-Time

Principal Scientist

Biology

Posted on 6/27/2024

Manifold Bio

Manifold Bio

11-50 employees

Designs precision biologics using in vivo methods

Biotechnology
Healthcare

Senior

Boston, MA, USA

Category
Public Health
Biology Lab & Research
Biology & Biotech
Requirements
  • PhD or equivalent experience in neuroscience and/or molecular biology, biological engineering or a related field
  • 10+ years of hands-on wet-lab experience, including 3+ years of startup/ biotech/pharma experience
  • Experience going end-to-end from experimental design through execution and data interpretation
  • Experience developing cell-based assays
Responsibilities
  • Design, execute, interpret, and iterate on cellular and biophysical assays to evaluate lead molecule activity and mechanism of action
  • Help nominate a data-driven lead molecule selection funnel
  • Conduct hypothesis-driven investigation of mechanism of action of lead molecules
  • Serve as in vitro pharmacology/toxicology lead expert for DC nomination and IND-enabling studies
  • Drive external work with CROs as needed
  • Provide expertise on late-breaking advances in neuroscience and neurodegenerative diseases

Manifold Bio focuses on creating precision biologics for the pharmaceutical industry. Their main product is an in vivo drug design platform, which allows for drug testing within living organisms rather than in laboratory settings. This platform utilizes mCodes™ technology, a unique protein barcoding system that enables the simultaneous study of multiple proteins in one experiment. This capability is especially beneficial for testing complex biologics, which are large molecule drugs derived from living organisms. Unlike other companies, Manifold Bio's approach to drug design is centered around in vivo testing, making it the first of its kind globally. The company's goal is to expand their platform and collaborate with other pharmaceutical companies to develop new therapeutics.

Company Stage

Series A

Total Funding

$58.8M

Headquarters

Boston, Massachusetts

Founded

2020

Growth & Insights
Headcount

6 month growth

-4%

1 year growth

-2%

2 year growth

0%
Simplify Jobs

Simplify's Take

What believers are saying

  • Raised $40M in Series A funding, indicating strong market interest.
  • Their platform could revolutionize in vivo testing by testing multiple molecules simultaneously.
  • Strategic partnerships with multiple investors enhance growth and development opportunities.

What critics are saying

  • Increased competition from companies like Insamo and Infinimmune.
  • Rapid AI and ML advancements may outpace Manifold Bio's current technology.
  • Regulatory challenges in in vivo testing could delay product development timelines.

What makes Manifold Bio unique

  • Manifold Bio uses proprietary mCodes™ technology for protein multiplexing in drug design.
  • Their in vivo drug design platform is the first of its kind globally.
  • The company specializes in precision biologics, focusing on complex biologics development.

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