Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.

We are seeking a highly motivated Junior Research Associate with a focus on Drug Metabolism and Pharmacokinetics (DMPK) to join our team. The ideal candidate will contribute to our efforts in pharmacokinetics screening, plasma protein binding, and microsomal assays. This role offers an exciting opportunity to work in a collaborative and fast-paced environment, supporting the development of cutting-edge therapies for cardiovascular and skeletal muscle disorders.

Responsibilities:

Bioanalysis: plasma and tissue processing/analysis to determine the drug concentration
Plasma Protein Binding Studies: Conduct experiments to determine the binding affinity of
compounds to plasma proteins using Sciex LC/MS-MS
Microsomal Assays: Perform microsomal stability studies to assess the metabolic stability and
run the assay using the Sciex LC/MS-MS
Perform bioanalytical analysis of small molecules in plasma and the tissue
using the Sciex LC/MS-MS.
Data Analysis and Interpretation: Analyze experimental data using appropriate software and
statistical methods and provide clear and concise summaries of findings to support decision-
making.
Documentation and Reporting: Maintain detailed records of experimental procedures, results,
and observations in laboratory notebooks and electronic databases. Prepare technical reports
and presentations for internal meetings and regulatory submissions.
Collaboration: Collaborate effectively with cross-functional teams, including medicinal
chemistry, pharmacology, and toxicology, to support drug discovery and development projects.
Lab Maintenance: Ensure proper maintenance and organization of laboratory equipment,
reagents, and supplies. Adhere to safety protocols and maintain a clean and safe working
environment.

Qualifications:

Bachelor’s or Master’s degree in Pharmaceutical Sciences, Chemistry, Biochemistry, or a related field with 2+ years of industry experience.
Hands-on experience with DMPK assays, including screening, plasma protein binding, and
microsomal assays are preferred but not required.
Proven analytical and problem-solving skills, with the ability to critically evaluate and interpret
experimental data.

Actual salary at the time of hire may vary and may be above or below the range based on various factors, including, but not limited to, the candidate’s relevant qualifications, skills, and experience, as well as the service line and location where this position may be filled.

Salary Pay Range

$52—$69 USD

Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.

Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.

Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer

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