Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus’ proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

We are looking for a highly skilled Research Scientist to join our Biological Modeling team to support Organoid Based Screening. Our CAP accredited facility develops human tumor models for use in a range of studies with our academic and commercial partners to discover next-generation cancer therapies. The ideal candidate will have a strong understanding of molecular gene editing, fluorescent imaging, image analysis, protein detection, and cell culture techniques. Post-doctoral and/or industry experience employing human organoid tissue models in high-throughput formats is preferred.

The successful candidate must be able to work in a fast-paced multidisciplinary environment and will be expected to communicate results both internally and to commercial partners.

What You’ll Do:

• Work in a collaborative, interdisciplinary team of scientists employing gene-editing approaches to perturb cellular pathways with the aim of identifying therapeutic targets
• Design and execute high-throughput gene-editing, imaging, and protein detection workflows
• Culture primary human tissue samples
• Work with automated liquid and plate platforms at all stages of development 
• Execute sequencing studies end-to-end
• Develop analysis pipelines to process and visualize large high-throughput data sets
• Generate summary reports of screening results and molecular data for customer deliverables

Qualifications:

• Ph.D. in oncology, molecular systems biology, or a related field
• 2+ years of industry or post-doctoral experience 
• Experience with 3D tissue models preferred, general cell culture experience is a must
• Experience generating and assessing next-generation sequencing data is preferred
• Proficiency in R and/or Python strongly preferred
• Experience with brightfield and fluorescent microscopy
• Experience coordinating complex experimental workflows across multidisciplinary teams
• Previous experience developing methods for and/or operating automated liquid handlers (Biomek, Echo, etc.)

Benefits:

• Competitive salary and benefits package
• Collaborative and supportive work environment
• Chance to make a real impact on the healthcare industry

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