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Senior/Scientist Engineer
Mrna Process Development
Confirmed live in the last 24 hours
Cambridge, MA, USA
Experience Level
  • PhD in Chemistry, Chemical Engineering, Biomedical Engineering or related discipline; 3-5 years industry experience. Master's degree with 5+ years of industrial experience. Strong background in bioprocess development of biologics, vaccines, nucleic acids (preferred)
  • Proficient with enzymatic reactions, mixing
  • Experience with UF/DF and chromatography purification a plus
  • Experience with analytical characterization techniques such as HPLC/UPLC, TEM, DSC, UV-Vis and fluorescence spectrophotometry to support process development
  • Familiarity with statistical design of experiments (DoE) and analysis
  • Strong organizational skills and ability to deal with complex problem solving, flexibility to adjust to changing priorities and willingness to mentor junior scientists
  • Highly self-motivated, driven, can-do, make it happen attitude with ability to own and drive projects
  • Strong collaborator with cross-functional teams and external partners
  • Excellent written and oral communications
  • Capable of continuous learning, open-minded, curious, highly organized and detail-oriented
  • Develop and optimize the mRNA synthesis manufacturing process, focusing on establishing robust control strategies for the in-vitro transcription (IVT) reactions, starting materials, and process conditions
  • Contribute to downstream process development for purification of mRNA
  • Define critical process parameters and characterize the mRNA process
  • Implement in process analytics to support understanding of IVT development
  • Contribute to mRNA production to meet needs of Research programs, pre-clinical in vivo studies, IND enabling and GMP clinical supplies
  • Perform data analysis and interpretation, communicate conclusions and present data and findings to cross-functional teams and company-wide events
  • Collaborate with mRNA discovery team to develop next generation mRNA process
  • Document all experimental planning and progress in electronic lab notebook; create and write reports and SOPs to support development, technology transfer, and regulatory filings
  • Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies
Prime Medicine

51-200 employees

Gene editing biotechnology company
Company Overview
Prime Medicine's mission is to transform the lives of patients with debilitating diseases through the application of our groundbreaking Prime Editing platform and technology. The company uses Prime Editing, a next-generation gene editing approach that they believe can address the genetic cause of disease and potentially provide patients with long-lasting cures.