Full-Time

Director – IT Commercial Applications

Posted on 9/13/2025

Amylyx Pharmaceuticals

Amylyx Pharmaceuticals

51-200 employees

Biopharmaceutical company developing neurodegenerative therapies

Compensation Overview

$204k - $230k/yr

Cambridge, MA, USA

Hybrid

Not accepting applicants from AK, AZ, HI, MI, TN; hybrid role with ~2 in-office days per week in New England.

Category
IT & Security (2)
,
Required Skills
Salesforce
Customer Service
Requirements
  • Bachelor’s degree in Computer Science or related field.
  • Minimum 10 years of progressive IT experience, including project and team management.
  • 5+ years of experience with CRM and customer engagement platforms (e.g., Salesforce.com, Veeva).
  • Strong understanding of service delivery and application lifecycle management.
  • Familiarity with data privacy regulations and their application to business operations.
  • Proven ability to lead cross-functional teams and manage external service providers.
  • Experience with enterprise systems and software vendor selection.
  • Excellent communication, analytical, and problem-solving skills.
  • Ability to prioritize tasks and make sound decisions under pressure.
  • Demonstrated success in managing IT projects within controlled change management frameworks.
  • Strong customer service orientation and interpersonal skills.
  • Self-motivated with high attention to detail.
Responsibilities
  • Build strong partnerships across business and technical teams to foster collaboration and effective project execution.
  • Lead the implementation and support of Commercial and Medical business-facing applications, ensuring alignment with strategic priorities.
  • Serve as the primary IT contact for audit and compliance matters related to Commercial and Medical systems, ensuring adherence to regulatory and internal controls.
  • Establish and maintain IT processes and standards for application support within the Commercial and Medical domains.
  • Oversee application enhancements and support activities in alignment with product launch and business objectives.
  • Act as a functional and technical advisor to define, estimate, and propose solutions for business opportunities.
  • Contribute to annual budgeting and planning for Commercial and Medical systems.
  • Administer CRM platforms (e.g., Salesforce, Veeva) for Commercial and Medical Affairs teams.
  • Manage vendor relationships, including assessments and contract negotiations.
  • Coordinate issue resolution with internal teams and external service providers.
  • Maintain the integration roadmap for Commercial and Medical applications (e.g., Commercial Data Environment, HUB, Aggregate Spend, Master Data Management).
  • Lead RFP processes, evaluate proposals, develop ROI analyses, and ensure proper documentation for IT initiatives.
  • Ensure compliance with regulatory requirements, including FDA computer systems assurance, SOX, and GDPR.
Desired Qualifications
  • Experience in Life Sciences, particularly within high-growth pharmaceutical or biotech environments.
  • Experience in Commercial, Marketing and/or Medical Operations within Life Sciences.
  • Strong customer service orientation and interpersonal skills.
  • Self-motivated with high attention to detail.
  • Proficiency in managing SaaS-based application implementations.
  • Strong analytical skills with the ability to translate business needs into technical requirements.
  • Experience with commercial applications and data warehousing.
  • Skilled in documenting and analyzing business requirements and functional specifications.
  • Effective facilitator of team collaboration and group sessions.
Amylyx Pharmaceuticals

Amylyx Pharmaceuticals

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Amylyx Pharmaceuticals develops treatments for neurodegenerative diseases, with a focus on ALS and Alzheimer's disease. Its main asset is AMX0035, currently in clinical trials, including the CENTAUR study for ALS and the PEGASUS study for late mild cognitive impairment or early dementia due to Alzheimer’s disease. The company advances products through rigorous, randomized, double-blind, placebo-controlled trials to demonstrate safety and efficacy before pursuing commercialization. In addition to research, Amylyx engages in awareness and community campaigns to support patients, caregivers, and researchers. The company aims to bring validated therapies to market to improve patient outcomes and generate revenue by selling treatments to healthcare providers and patients.

Company Size

51-200

Company Stage

IPO

Headquarters

Cambridge, Massachusetts

Founded

2013

Simplify Jobs

Simplify's Take

What believers are saying

  • Post-bariatric hypoglycemia has no FDA-approved therapies, creating a clear unmet-need launch opportunity.
  • Amylyx ended Q1 2026 with $279.8 million cash, funding operations into 2028.
  • TCG Crossover's 5.7% stake signals specialist investor confidence in the endocrine pipeline.

What critics are saying

  • PHOENIX failed in ALS, leaving AMX0035 without a validated commercial franchise.
  • LUCIDITY topline data in Q3 2026 is binary; a miss delays first revenue.
  • Expanded access exposure before approval can surface adverse events and weaken avexitide's regulatory story.

What makes Amylyx Pharmaceuticals unique

  • Amylyx now centers on avexitide, a first-in-class GLP-1 antagonist for post-bariatric hypoglycemia.
  • LUCIDITY fully enrolled in May 2026, with topline results expected in Q3 2026.
  • The U.S. Expanded Access Programme, launched May 5, 2026, broadens physician and patient exposure.

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Your Connections

People at Amylyx Pharmaceuticals who can refer or advise you

Benefits

Remote Work Options

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

-2%

2 year growth

-16%
Business Wire
Apr 8th, 2026
Amylyx Pharmaceuticals to present at the 25th Annual Needham Virtual Healthcare Conference.

Amylyx Pharmaceuticals to present at the 25th Annual Needham Virtual Healthcare Conference. CAMBRIDGE, Mass.-(BUSINESS WIRE)-Amylyx Pharmaceuticals, Inc. (Nasdaq: AMLX) ("Amylyx" or the "Company") today announced that management will present at the 25th Annual Needham Virtual Healthcare Conference. The corporate presentation will take place on Wednesday, April 15, 2026, at 8:45 a.m. ET. A live webcast of the presentation can be accessed under "Events and Presentations" in the Investor section of the Company's website, https://investors.amylyx.com/events-presentations, and will be available for replay for 90 days following the event. About Amylyx Pharmaceuticals At Amylyx, our mission is to usher in a new era of treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are currently focused on four investigational therapies across several endocrine conditions and neurodegenerative diseases in which we believe can make the greatest impact. For more information, visit amylyx.com and follow us on LinkedIn and X. For investors, please visit investors.amylyx.com. Contacts. Investors Lindsey Allen Amylyx Pharmaceuticals, Inc. +1 (857) 320-6244 [email protected] More News From Amylyx Pharmaceuticals, Inc. CAMBRIDGE, Mass.-( BUSINESS WIRE )-Amylyx Pharmaceuticals Announces Completion of Enrollment in Pivotal Phase 3 LUCIDITY Clinical Trial of Avexitide in Post-Bariatric Hypoglycemia... CAMBRIDGE, Mass.-( BUSINESS WIRE )-Amylyx Pharmaceuticals, Inc. (Nasdaq: AMLX) ("Amylyx" or the "Company") today reported financial and business results for the fourth quarter and full year ended December 31, 2025. "2025 was a year of meaningful advancement for Amylyx's pivotal avexitide program in post-bariatric hypoglycemia, as well as progress across our broader pipeline," said Joshua Cohen and Justin Klee, Co-CEOs of Amylyx. "In 2026, our primary focus is on our Phase 3 LUCIDITY trial of av... CAMBRIDGE, Mass.-( BUSINESS WIRE )-Amylyx Pharmaceuticals to Participate in Upcoming March Investor Conferences...

Yahoo Finance
Mar 28th, 2026
Amylyx completes enrollment in Phase 3 trial of first-in-class therapy for post-bariatric hypoglycemia

Amylyx Pharmaceuticals has completed enrolment in LUCIDITY, its pivotal Phase 3 trial of avexitide for post-bariatric hypoglycaemia following Roux-en-Y gastric bypass surgery. The 16-week, double-blind, placebo-controlled study has randomised and dosed its final participant. The milestone positions Amylyx to potentially file for approval of a first-in-class GLP-1 receptor antagonist for a condition with no FDA-approved therapies. Topline results are expected in Q3 2026. Earlier trials showed consistent reductions in severe hypoglycaemic events. The company maintains a $317 million cash balance to support trial milestones but remains loss-making. Analyst forecasts project revenues of $107.8 million and earnings of $23.1 million by 2029, though estimates vary considerably.

Yahoo Finance
Mar 4th, 2026
Amylyx completes LUCIDITY Phase 3 recruitment, pivots to Avexatide and GLP-1 antagonist

Amylyx Pharmaceuticals has completed recruitment for its pivotal Phase 3 LUCIDITY trial of Avexatide for post-bariatric hypoglycemia and is shifting its core focus towards the drug whilst preparing for potential expedited regulatory submission once top-line data becomes available later this year. The company has also nominated AMX318, a GLP-1 antagonist, as a new development candidate. Trading at $14.11, Amylyx shares are up 23.6% year-to-date and 368.8% over one year, though down 60.7% over three years. With a 2025 net loss of $144.74 million and minimal revenue, Amylyx is streamlining legacy programmes and reallocating spending. The company has filed a universal shelf registration including $100.87 million tied to common stock, signalling potential future equity issuance.

Aktiencheck.de AG
Feb 18th, 2026
TCG Crossover takes 5.7% stake in Amylyx Pharmaceuticals

TCG Crossover has acquired a 5.7% stake in Amylyx Pharmaceuticals, according to recent regulatory filings. The investment firm, through its Fund II and associated entities, now holds 6,243,812 shares of the biotechnology company. The filing classifies this as a passive investment, indicating no current intention to influence corporate strategy or management. The stake is based on 109.8 million total shares outstanding as of last October. For Amylyx, securing backing from established institutional investors typically contributes to shareholder base stability. The investment suggests professional capital allocators view the company's development projects favourably. Future stock performance will primarily depend on clinical trial outcomes, regulatory milestones and data releases from the company's pipeline.

Yahoo Finance
Feb 1st, 2026
Amylyx co-CEO sells 138K shares for $1.9M to cover option exercise costs

Amylyx Pharmaceuticals Co-Chief Executive Joshua B Cohen exercised 200,000 stock options and sold 138,167 shares on 15-16 January for approximately $1.9 million. The sale was conducted to cover option costs and tax obligations, not as a discretionary decision. The transaction reduced Cohen's direct holdings by 3.93% to 3,379,465 shares, representing an estimated 4.07% insider ownership. The shares sold significantly exceeded his historical median sell size of 15,220 shares. Amylyx is a clinical-stage biotechnology company focused on neurodegenerative diseases and endocrine conditions. Its flagship therapy, AMX0035, has shown effectiveness in slowing ALS progression. The company's share price rose approximately 223% in 2025, with market capitalisation reaching $1.57 billion. It's also advancing avexitide, a phase three candidate for treating hypoglycemia.

INACTIVE