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Senior Scientist
Computational and Systems Biology, Predictive Sciences
Posted on 7/8/2022
INACTIVE
Locations
San Diego, CA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Desired Skills
R
Research
Python
MATLAB
Requirements
  • Ph.D. in computational biology or systems biology with 2+ years of post-doctoral experience in applying computational and analytical approaches in university, pharma, or biotech settings, focusing on drug discovery, or elucidating underlying disease pathology
  • Systems biology methods focused on both casual and correlative inferences
  • Extensive experience in analyzing perturbation data from a wide variety of molecular profiles such as transcriptomics and proteomics in an integrative fashion
  • Knowledge of various public perturbation repositories and ingestion of data from these repositories for internal use
  • Ability to work with noisy and missing data to tease out relevant information
  • Expertise in programming and scripting languages (R, Python, or Matlab)
  • Knowledge of various parametric and non-parametric statistical tests and ability to identify and apply the appropriate statistical test
  • Excellent verbal and written communication skills
Responsibilities
  • Integrate multi-dimensional compound profiling data from proteomics, transcriptomics, and phenomics screens to elucidate compound activities
  • Interpret compound MoA by mapping and analyzing compound perturbation in the context of cellular pathways and biological networks
  • Predict a compound's therapeutic effect by linking compound perturbations with molecularly defined primary disease states
  • Collaborate with toxicology group to analyze compound profiling data for early identification of potential safety liabilities
  • Design and implement systems biology approaches to prioritize novel drug targets and compound MoAs
  • Help create knowledge-graph from internal and external datasets to facilitate navigation of knowledgebase
  • Author scientific reports, and present methods, results, and conclusions to publishable standard
  • Contribute to planning and execution of collaborative projects with leading academic and commercial research groups worldwide
Desired Qualifications
  • Experience in machine learning/deep learning
  • Knowledge of drug discovery in pre-clinical and early phase drug development stages
Bristol-Myers Squibb

10,001+ employees

Biopharmaceutical development company
Company mission
Bristol-Myers Squibb engages in the discovery, development, licensing, manufacturing, marketing, distribution and sale of pharmaceuticals.