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Senior Scientist-Oligonucleotide Synthesis
P-3089
Confirmed live in the last 24 hours
Locations
Pleasanton, CA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Requirements
  • PhD. in Chemistry, Biochemistry, Chemical Engineering, or related field
  • 3+ years industry experience in oligonucleotide manufacturing process development and/or manufacturing
  • Extensive experience with plate-based oligonucleotide synthesis instrumentation (e.g. Dr Oligo, Mermade) and subsequent plate-based downstream processing
  • Proven hands-on experience in the synthesis, purification, and QC of oligonucleotides as evidenced by peer-reviewed publications, published patents, or commercialized products
  • Expert technical knowledge of nucleotide modifications and oligonucleotide synthesis, purification, and QC methods, techniques, strategies, and equipment
  • Ability to meticulously design and execute on meaningful experiments and perform in-depth analyses of the resultant data. Experience using statistical tools, such as JMP, is beneficial
  • Exceptionally strong troubleshooting and problem-solving skills
  • Ability to integrate a broad range of scientific and engineering disciplines
  • Experience developing and implementing novel QC methods to assess reagent performance in both functional and orthogonal assays
  • Proven track record of ability to develop, validate, and transfer processes to manufacturing or OEM vendors
  • Strong process transfer experience, demonstrating control of manufacturing processes through appropriate Process Design and QC methods
  • Proven ability to write SOPs and train others to successfully perform the work
  • Strong organizational, collaboration, and written and oral communication skills
  • Desire to be part of a rapidly evolving organization with the ability to work in a fast-paced and quickly changing environment
  • Experience in GMP, GLP setting and good documentation practices preferred
  • Experience using statistical tools, such as JMP to analyze complex data sets, create DOE experiments, and data trending
  • Previous work guiding the development of new manufacturing and production infrastructure
  • Experience operating liquid handling robots and other common laboratory automation tools, ability to program these instruments would be very beneficial
Responsibilities
  • Leading the conception, development, and optimization of robust, high-throughput, plate-based oligonucleotide manufacturing methods and processes in preparation for transfer to production
  • Establishing suitable purification processes for diverse classes of oligonucleotides with varying physical properties at different scales
  • Planning and performing systematic workflow and reagent optimization by modeling, guard band studies, identification of critical factors, and use of formal design of experiment (DOE) approaches. This includes in-depth analysis and reporting of your data through documentation and presentations to internal groups
  • Identifying and optimizing any compounding factors, such as temperature, environment, workflow, pressures, reagent concentrations, etc. that could impact the resulting product
  • Developing and validating new QC methods to assess the suitability, stability, and functionality of a range of oligonucleotides through a variety of analytical and functional tests
  • Implementing routine process QC methods to ensure processes are in control
  • Identification and implementation of statistical process control tools
  • Verifying that the manufactured products output meets all predetermined requirements
  • Driving the technology transfer phase as new products move from process development into manufacturing in preparation for commercial launch
  • Installation and verification of equipment, documenting processes, and training operators
  • Independently troubleshooting and resolving reagent formulation, process, QC, and incoming material issues
  • Providing technical leadership in the production and analysis of oligonucleotides to identify continuous improvement opportunities
  • Guiding infrastructure requirements to build out internal oligonucleotide manufacturing capabilities
  • Working closely with computational and molecular biologists to interpret data generated by novel assays
10x Genomics

201-500 employees

DNA sequencing insight platform
Company Overview
10x Genomics is on a mission to develop innovative instruments, reagents, and software that allow you to see your biological system at a resolution that matches its complexity. The company enables scientists to advance their research, allowing them to address scientific questions they did not even know they could ask.
Benefits
  • Comprehensive health benefits
  • Generous time off
  • Parental leave
Company Core Values
  • We are mission driven and stay relentlessly focused on that mission.
  • We operate from first principles.
  • We strive for exponential impact.
  • We put WE before ME.
  • We believe exceptional talent delivers outsized results.