Research Associate

Key responsibilities for this position include:

• Establish and quantify readouts for in vivo efficacy, biodistribution, and other effects of dosed articles in animal models of rare genetic disorders 
• Maintain, genotype and characterize mutant mouse lines and their associated phenotypes, as well as assist with animal husbandry 
• Execute and/or troubleshoot diverse assays – physiological, behavioral, or tissue-based - perform relevant analysis, document all experimental details and results 
• Assist with experiments using cultured cells, virus vector production and/or titration and execute assays for DNA/RNA and/or protein quantification
• Perform surgical procedures on animal models using multiple dosing routes 
• Work with team members to regularly update electronic lab notebook (ELN) prepare high quality reports and scientific presentations 
• Be up to date with relevant scientific literature and adapt to changes in priorities. 

Qualifications:

• A BS/MS in Neuroscience, Physiology, Molecular/Cellular Biology, or a related Life Science discipline, with 0-2 years’ experience working in a life science research lab. 
• Hands-on experience working with rodent animal models (mouse or rat) – including animal handling and husbandry is required 
• Candidates with experience in post-hoc procedures including tissue extraction, embedding and processing, immunohistochemistry (IHC), protein/nucleic acid extractions and/or PCR based methods (e.g., qPCR, ddpCR) will be preferred. 
• Additional experience with one of the following methods will be a plus: in situ Hybridization (ISH), RNAscope, imaging/microscopy, image anaylsis as well protein detection/quantification methods such as Western Blot, ELISA, etc. 
• Familiarity with various dosing routes in mice – including (but not limited to) Intracerebroventricular (ICV), intrathecal(IT), Intravenous(IV), Intra-muscular (IM), Intraparenchymal routes – is desirable. 
• Experience with mouse/rat behavior assays (e.g. open field, rotarod) would be good to have but not required. 
• Ability to work collaboratively with colleagues and effectively handle and prioritize multiple tasks in a fluid, fast-paced work environment 
• Ability to master new concepts quickly, highly organized, with excellent oral and written communication skills