Full-Time

Scientist/Senior Scientist

Analytical Sciences

Confirmed live in the last 24 hours

Korro Bio

Korro Bio

51-200 employees

Develops RNA-based therapies for diseases

Biotechnology
Healthcare

Senior

Cambridge, MA, USA

Hybrid position at 60 first st, Cambridge, MA 02141.

Category
Bioinformatics
Computational Biology
Genomics
Public Health
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis
Requirements
  • PhD in Analytical Chemistry, Biochemistry, Molecular Biology, or related field; or MS with 5+ years of relevant industry experience.
  • 3+ years of hands-on experience in analytical method development for biologics, with experience in RNA therapeutics preferred.
  • Expertise in chromatographic (e.g., UPLC -UV, and UPLC-MS) and spectroscopic techniques (e.g., UV-Vis), with a strong understanding of method validation requirements. Experience with fluorescence, IR and NMR is a plus.
  • Familiarity with cGMP and ICH guidelines for analytical development and quality control of biologics.
  • Experience with stability studies, impurity profiling, and degradation pathways.
  • Strong analytical skills with the ability to troubleshoot and solve complex technical problems.
  • Excellent written and verbal communication skills, with experience drafting technical reports and regulatory documents.
  • Ability to work collaboratively in a fast-paced environment and manage multiple projects simultaneously.
Responsibilities
  • Develop and optimize analytical methods for the characterization, quantification, and release of RNA-based drug substances and products.
  • Perform routine and non-routine testing, including HPLC, UV-Vis, mass spectrometry, and other relevant techniques, to assess product quality and stability.
  • Support analytical method validation, transfer, and troubleshooting to ensure compliance with cGMP standards.
  • Collaborate with the Process Development and Quality Control teams to ensure seamless integration of analytical methods into manufacturing workflows.
  • Analyze, interpret, and present complex data to cross-functional teams and senior management.
  • Author and review technical reports, protocols, SOPs, and sections of regulatory filings (IND, IMPD etc.).
  • Assist in managing external analytical collaborations with CROs and CMOs, ensuring data quality and timelines are met.
  • Stay current with emerging analytical technologies and apply innovative solutions to improve method robustness and efficiency.
  • Support investigations and root cause analyses for any out-of-specification (OOS) results, deviations, or process failures.

Korro Bio develops RNA-based therapies aimed at treating serious diseases that lack effective treatments. Their approach utilizes RNA editing, which allows for precise changes at the RNA level to modify protein function, offering a more accurate alternative to traditional gene editing methods. This company stands out from competitors by focusing on single base edits, which are considered less risky. Korro Bio's goal is to advance medical treatments through extensive research and development, ultimately bringing new therapies to market either independently or through partnerships with larger pharmaceutical companies. They aim to provide hope to patients in need and collaborate with academic institutions to enhance their scientific research.

Company Stage

IPO

Total Funding

$383.7M

Headquarters

Cambridge, Massachusetts

Founded

2019

Growth & Insights
Headcount

6 month growth

1%

1 year growth

0%

2 year growth

8%
Simplify Jobs

Simplify's Take

What believers are saying

  • Korro Bio raised $70M for clinical trials and growth in April 2024.
  • Partnership with Novo Nordisk targets cardiometabolic diseases like obesity and diabetes.
  • Recent FDA approvals support RNA-based treatments, benefiting Korro Bio's pipeline.

What critics are saying

  • Potential competition from RNA editing companies like Beam Therapeutics.
  • Merger with Frequency Therapeutics may lead to integration challenges.
  • Stock price surge could lead to market volatility and investor scrutiny.

What makes Korro Bio unique

  • Korro Bio uses RNA editing for precise protein function modifications.
  • Their platform targets diseases with limited or no current treatment options.
  • Korro Bio's RNA editing is considered superior to traditional gene editing.

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