Full-Time

Scientist/Senior Scientist

Analytical Sciences

Confirmed live in the last 24 hours

Korro Bio

Korro Bio

51-200 employees

Develops RNA-based therapies for diseases

Biotechnology
Healthcare

Mid, Senior

Cambridge, MA, USA

Hybrid position.

Category
Bioinformatics
Computational Biology
Genomics
Public Health
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis
Requirements
  • PhD in Analytical Chemistry, Biochemistry, Molecular Biology, or related field; or MS with 5+ years of relevant industry experience.
  • 3+ years of hands-on experience in analytical method development for biologics, with experience in RNA therapeutics preferred.
  • Expertise in chromatographic (e.g., UPLC -UV, and UPLC-MS) and spectroscopic techniques (e.g., UV-Vis), with a strong understanding of method validation requirements. Experience with fluorescence, IR and NMR is a plus.
  • Familiarity with cGMP and ICH guidelines for analytical development and quality control of biologics.
  • Experience with stability studies, impurity profiling, and degradation pathways.
  • Strong analytical skills with the ability to troubleshoot and solve complex technical problems.
  • Excellent written and verbal communication skills, with experience drafting technical reports and regulatory documents.
  • Ability to work collaboratively in a fast-paced environment and manage multiple projects simultaneously.
Responsibilities
  • Develop and optimize analytical methods for the characterization, quantification, and release of RNA-based drug substances and products.
  • Perform routine and non-routine testing, including HPLC, UV-Vis, mass spectrometry, and other relevant techniques, to assess product quality and stability.
  • Support analytical method validation, transfer, and troubleshooting to ensure compliance with cGMP standards.
  • Collaborate with the Process Development and Quality Control teams to ensure seamless integration of analytical methods into manufacturing workflows.
  • Analyze, interpret, and present complex data to cross-functional teams and senior management.
  • Author and review technical reports, protocols, SOPs, and sections of regulatory filings (IND, IMPD etc.).
  • Assist in managing external analytical collaborations with CROs and CMOs, ensuring data quality and timelines are met.
  • Stay current with emerging analytical technologies and apply innovative solutions to improve method robustness and efficiency.
  • Support investigations and root cause analyses for any out-of-specification (OOS) results, deviations, or process failures.

Korro Bio develops RNA-based therapies aimed at treating serious diseases that currently lack effective treatments. The company uses RNA editing to make precise modifications at the RNA level, which allows for accurate changes to protein function. This method is seen as more precise and potentially safer than traditional gene editing techniques. Korro Bio focuses on research and development to create new therapies, which it can market independently or through partnerships with larger pharmaceutical companies. The company serves healthcare providers, hospitals, and patients, and collaborates with academic institutions to enhance its research. Korro Bio's goal is to make significant scientific advancements in medicine accessible to patients in need.

Company Stage

IPO

Total Funding

$383.7M

Headquarters

Cambridge, Massachusetts

Founded

2019

Growth & Insights
Headcount

6 month growth

1%

1 year growth

0%

2 year growth

8%
Simplify Jobs

Simplify's Take

What believers are saying

  • Korro Bio raised $70M for clinical trials and growth in April 2024.
  • Partnership with Novo Nordisk targets cardiometabolic diseases like obesity and diabetes.
  • FDA's approval of RNA-based therapy could accelerate Korro Bio's regulatory pathway.

What critics are saying

  • Potential competition from Beam Therapeutics in RNA editing technologies.
  • Merger with Frequency Therapeutics may lead to integration challenges.

What makes Korro Bio unique

  • Korro Bio uses RNA editing for precise protein function modifications.
  • Their platform targets diseases with limited or no current treatment options.
  • Korro Bio's RNA editing is considered superior to traditional gene editing.

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