Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Spring 2025 semester with experience in cell and molecular biology to join the Auditory & Ocular team. The candidate will work in a highly collaborative team to develop assays, identify, and validate promising Prime Editors for auditory and ocular indications.

The candidate will have an opportunity to learn and refine cell and molecular biology skills, develop an understanding of gene editing, and learn about auditory and ocular biology. We are looking for an enthusiastic, quick learner interested in gaining experience in a fast-paced industrial research setting.

Primary Responsibilities:

Aseptic mammalian cell culture, including passaging and performing transfections to evaluate Prime Editor activity.
Cloning of Prime editor components into suitable expression vectors
DNA, RNA, and protein extraction from in vitro and in vivo samples
Sample preparation to confirm Prime Editing using various techniques including NGS, ddPCR, qPCR, and ELISAs
Data analysis, interpretation, and team presentation
Electronic lab notebook documentation

Required Qualifications:

B.S/M.S. candidate in Cell & Molecular Biology or related major
Basic knowledge of molecular biology, cell biology and biochemistry.
Excellent troubleshooting and communication skills
Ability to work independently and within a team

Preferred Qualifications:

Hands-on experience with cell culture is preferred
Experience/knowledge of cloning (primer design, vector construction, Gibson, golden gate, site-directed mutagenesis, etc.)
Familiarity with molecular biology procedures such as qPCR, ddPCR and NGS
Familiarity with Excel and PowerPoint for data analysis and presentation
Prior industry co-op experience

What We Offer:

A cutting-edge team open to mentorship and networking.
Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
Participation in regular seminars with industry experts.
Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2025 Co-op: Cell & Molecular Biology

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