In this role, you will:

• ​​Develop in vitro and in vivo assays for assessing lysosome function, autophagic flux, and pathways related to accumulation diseases
• Develop overexpression, knock-in, and knock-out cell lines using CRISPR and viral approaches
• Provide scientific insights and in-depth data interpretation to inform decision-making within the research team
• Serve as a technical expert in resolving technical and workflow issues, drawing conclusions, and making recommendations; interact with other departments as necessary to plan and expedite project objectives
• Perform a wide range of functional cell-based assays including but not limited to quantitative molecular biology, cell imaging, and mechanism of action studies.
• Work both independently and in close collaboration to generate high-quality data in a fast-paced and dynamic environment
• Stay current with relevant scientific literature and implement new techniques or practices to improve quality and efficiency

You might thrive in this role if you:

• PhD in cell biology or related discipline with at least 2 years of post-doctoral or industry experience
• Have extensive experience with lysosome and autophagy biology
• Have experience handling rodents and working with models of lysosomal accumulation, including neurodegeneration
• Have hands-on experience in the development, optimization, and execution of cellular assays, applying multiple techniques including primary cell isolation, tissue culture, ELISA, flow cytometry, and Western and multiplexing technologies
• Are able to learn and embrace new technologies quickly, work independently, multi-task, and manage shifting priorities
• You are energetic, detail-oriented, intellectually curious, and deeply pragmatic. You thrive in a culture that embraces rapid iteration and open, straightforward communication
• Have a burning desire to understand aging biology through the lens of modern data-rich measurement technologies