Full-Time

Senior Cost Accounting and Manufacturing Operations Manager

Cost Accounting & Manufacturing Operations

Sarepta

Sarepta

1,001-5,000 employees

Develops gene therapies for rare diseases

Compensation Overview

$136k - $170k/yr

Bedford, MA, USA

Hybrid

Hybrid role; on-site at Sarepta facility in the United States with some in-person events.

Category
Accounting (2)
,
Required Skills
Forecasting
Oracle
Requirements
  • Bachelor’s and/or master’s degree in accounting/finance or similar.
Responsibilities
  • Developing a strong business partner relationship with the Manufacturing, QA, QC, and Process Development functions.
  • Managing a financial performance management platform for the Technical Operations Organization.
  • Manage Inventory and Manufacturing Finance Costing Team.
  • Manage and complete the monthly accounting close process related to inventory, manufacturing, and clinical trials, ensure compliance with U.S. GAAP.
  • Analyze and validate all inventory transactions in Oracle.
  • Develop, implement, and maintain a standard cost accounting process for our manufacturing operation, including performing periodic cost studies in support of our standard cost model and the regular investigation, resolution and reporting of actual-to-standard variances.
  • Work directly with Third Party vendors to ensure accurate monthly reports.
  • Develop and maintain inventory cycle counting process.
  • Provide business analysis, forecasting and budgeting with the Technical Operations organization in partnership with our FP&A group, including making recommendations for financial and operational improvements.
  • Maintain and make recommendations to improve our system of internal accounting controls as they relate to inventory and manufacturing.
  • Work within our existing Oracle ERP system and the Oracle Process Manufacturing module, lead efforts to recommend and implement any expansions of this system.
  • Manage the preparation of the internal and external reporting related to these key areas, including internal monthly reporting and quarterly reporting to be filed with the SEC and assist in the external audit functions.
  • Develop monthly inventory reports for Finance leadership and business partners to support analytics and strategic decision making.
  • Develop monthly flux analytics to support SEC filings.

Sarepta Therapeutics focuses on developing precision genetic medicines to treat rare diseases. It specializes in Duchenne muscular dystrophy (DMD) and is advancing gene therapies for limb-girdle muscular dystrophy (LGMD), Charcot-Marie-Tooth disease, MPS IIIA, and other CNS disorders. The company conducts research and development, carries therapies through clinical trials, and seeks regulatory approvals to bring treatments to patients, earning revenue from approved therapies and strategic partnerships. Its goal is to speed up drug development from lab research to patient treatment and to build the world’s largest gene therapy manufacturing capacity to meet global demand.

Company Size

1,001-5,000

Company Stage

IPO

Headquarters

Cambridge, Massachusetts

Founded

1980

Simplify Jobs

Simplify's Take

What believers are saying

  • Q1 2026 revenue hits $731 million, beating estimates by 56%.
  • $700 million notes refinanced to 2030, bolstering $954 million cash.
  • $600 million credit facility funds ELEVIDYS reset and pipeline advances.

What critics are saying

  • FDA denies AMONDYS 45, VYONDYS 53 conversions, slashing $228 million revenue.
  • Elevidys triggers permanent FDA restrictions after liver injuries, zeroing sales.
  • CEO Ingram retires end-2026, sparking talent exodus and pipeline delays.

What makes Sarepta unique

  • Sarepta leads DMD with PMO therapies generating $229 million in Q1 2026.
  • ELEVIDYS delivers 70-73% slower DMD progression in EMBARK Phase III trial.
  • Pipeline expands to DM1, FSHD siRNA and Huntington's trials by H1 2026.

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Benefits

Wellness Program

Company News

Yahoo Finance
Mar 23rd, 2026
Sarepta seeks FDA approval conversion for AMONDYS 45 and VYONDYS 53 using ESSENCE Phase 3 data

Sarepta Therapeutics has received FDA agreement to file supplemental applications by end of April seeking conversion of AMONDYS 45 and VYONDYS 53 from accelerated to traditional approvals, using data from the ESSENCE Phase 3 study and real-world evidence in Duchenne muscular dystrophy. The regulatory conversion could validate Sarepta's exon-skipping platform and strengthen its DMD franchise durability. However, the company faces ongoing safety concerns around its gene therapy ELEVIDYS. Sarepta is enrolling non-ambulant patients to test an enhanced immunosuppression regimen, with primary endpoints focused on acute liver injury incidence. The company's narrative projects $1.4 billion revenue and $171.6 million earnings by 2028, implying 17% annual revenue decline. Most optimistic analysts forecast $713.6 million earnings on $1.9 billion revenue by 2028.

Yahoo Finance
Mar 3rd, 2026
Bavarian Nordic CEO steps down amid pharma leadership shake-up

Bavarian Nordic has announced that CEO Paul Chaplin will step down after 11 years leading the Danish vaccine specialist, marking the latest executive change in pharmaceuticals this year. Chaplin, who joined in 2014, is leaving for personal reasons as his family relocates to Australia. He will remain until year-end or until a successor is found. The move follows recent departures elsewhere. Sarepta's Doug Ingram announced his retirement last month after a decade as CEO, citing family health concerns. Sanofi revealed in February it would not renew Paul Hudson's contract after six years, with share prices falling over 20% since February 2025. Belén Garijo, currently CEO of Merck KGaA, will take over at Sanofi from 29 April.

Yahoo Finance
Mar 1st, 2026
Wells Fargo cuts Sarepta Therapeutics price target to $38 from $45 after GTx launch delays

Wells Fargo has cut its price target on Sarepta Therapeutics to $38 from $45, maintaining an Overweight rating. The firm adjusted its ELEVIDYS projections, noting the gene therapy launch reset following safety events may take longer than anticipated based on 2026 guidance. However, Wells Fargo expects positive results from the company's siRNA readout. Separately, Baird reduced its price target to $20 from $22 with a Neutral rating following Sarepta's fiscal 2025 results. The company reported full-year net product revenues of $1.864 billion, comprising $965.6 million from PMO products and $898.7 million from ELEVIDYS. Sarepta Therapeutics develops RNA-targeted therapeutics and gene therapy for rare diseases, with several approved treatments for Duchenne muscular dystrophy.

Yahoo Finance
Feb 26th, 2026
Sarepta Therapeutics CEO Ingram to retire after tumultuous year for gene therapy Elevidys

Sarepta Therapeutics CEO Douglas Ingram will retire by the end of 2026 or upon appointment of his successor, the company announced in a regulatory filing. The firm has begun searching for his replacement. Ingram's departure follows a turbulent 2025 for the biotech company. Its gene therapy Elevidys, used to treat a muscle disorder, was linked to two patient deaths, prompting the FDA to request voluntary shipment halts. The company cut 500 jobs and halted development of several gene therapies. Elevidys carries the FDA's most serious safety warning and requires stringent monitoring. Despite the setbacks, Ingram said on Wednesday the therapy is on a potential pathway for expanded use. Sarepta's shares fell 82% last year and were down 4% in after-market trading. Ingram has led the company since 2017.

Yahoo Finance
Feb 26th, 2026
Sarepta posts $1.86B revenue, guides $1.2B–$1.4B for 2026 as CEO plans retirement

Sarepta Therapeutics reported 2025 net product revenue of $1.86 billion, comprising $966 million from its PMO franchise and $899 million from ELEVIDYS. The company guided 2026 approved-therapy revenue between $1.2 billion and $1.4 billion, whilst ending 2025 with $954 million in cash. Management described 2026 as a commercial "critical reset" for ELEVIDYS following two fatal events in 2025. Clinically, EMBARK three-year data showed a statistically significant 4.39-point NSAA benefit and approximately 70–73% slowing on key functional measures. Proof-of-concept readouts for DM1 and FSHD siRNA programmes are expected by end-Q1, with a Huntington's trial to begin in H1 2026. CEO Doug Ingram announced plans to retire around end-2026, with the board conducting a comprehensive successor search.