Senior Research Scientist
In Vivo Pharmacology
Confirmed live in the last 24 hours
Vancouver, BC, Canada
Experience Level
Desired Skills
  • Working collaboratively with biology, protein engineering and PK scientists to generate in vivo proof-of-concept for lead validation, executing efficient PK/PD assessments and advancing programs to clinical development
  • Designing and executing/monitoring in vivo pharmacology and pharmacodynamic studies in immuno-oncology and other disease indications
  • Using detailed knowledge of state-of-the-art tools to enhance in vivo evaluation of antibody therapeutic mechanism of action
  • Developing, performing or overseeing supporting assays (e.g., receptor occupancy, immunoprecipitation, western blot, deep sequencing, RT-PCR, FACS) to assess target modulation levels and downstream effects at cellular, protein and gene level
  • Developing, executing or monitoring secondary ex vivo cell-based assays across various technology platforms (e.g., cell sorting, imaging, co-culture systems)
  • Preparing nonclinical pharmacology sections and strategy that support IND and clinical trial applications
  • Collaborating with teams across the company to solve problems, analyze, interpret and communicate data
  • Evaluating new technology and testing new models to better predict human illness
  • Reporting findings to our teams and partners to support data-driven decision making
  • You are genuinely curious, with an interest in discussing innovative ideas in a highly collaborative and face paced environment
  • You are good at communicating scientific and/or technical concepts with an emphasis on application
  • You are strongly self-motivated and work independently to identify project needs and follow that up with constructing and implementing solutions
  • You enjoy the teamwork that comes with working on complicated biological questions and building data sets that help to predict the success of therapies
  • PhD in Pharmacology, Biology or related discipline with working knowledge of the drug development process and 8+ years practical work experience in a biopharmaceutical industry environment
  • Experience with preclinical R&D of immuno-oncology therapeutics
  • Demonstrated proficiency in nonclinical development of large molecules/biologics from discovery to mid-stage development
  • Significant experience with authoring/reviewing study protocols and reports to ensure appropriate datasets are accurately generated and interpreted
  • Exceptional analytical and problem-solving capabilities
  • Excellent documentation, organizational and communication skills
  • Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional team
Desired Qualifications
  • Understanding of regulatory processes as well as GLP/ICH and other guidance documents
  • Experience with assessing new and emerging in silico / in vitro technologies to improve human prediction for antibody drug development
AbCellera Biologics
Company Overview
AbCellera Biologics is a biotechnology company that develops antibody therapeutics to improve patient outcomes.