Full-Time

Manufacturing Supervisor

Takeda

Takeda

10,001+ employees

Global biopharmaceutical firm; R&D-driven NMEs

Compensation Overview

$89.9k - $141.2k/yr

Los Angeles, CA, USA

In Person

On-site in Los Angeles, CA; occasional travel up to 5%.

Bachelor's

Category
Manufacturing & Production Operations
Required Skills
Six Sigma

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Requirements
  • High School Diploma or GED plus 6+ years of related experience OR bachelor's degree in science, engineering or other related technical field and 3+ years of related experience. Some leadership experience preferred for Supervisor role.
  • Experience in a regulated manufacturing environment, preferably in pharmaceutical, biotechnology, or other cGMP-regulated operations.
  • Prior experience leading, coordinating, or directing the work of manufacturing employees, such as operators, technicians, or leads, preferred.
  • Working knowledge of cGMP, Good Documentation Practices, data integrity principles, and quality requirements in a manufacturing environment.
  • Basic understanding of deviations, investigations, CAPAs, and change control processes.
  • Familiarity with continuous improvement and problem-solving tools such as Lean, DMAIC, Six Sigma, or similar methodologies preferred.
  • Ability to troubleshoot routine operational issues and collaborate with support groups for timely resolution.
  • Strong organizational and time management skills, with the ability to manage multiple priorities in a fast-paced manufacturing setting.
  • Effective verbal and written communication skills, with the ability to communicate clearly with team members, peers, and support functions.
  • Demonstrated interpersonal skills and the ability to coach, support, and develop employees in a team-oriented environment.
  • Working knowledge of environmental, health, and safety practices and the ability to reinforce safe work behaviors.
  • Familiarity with manufacturing, training, and business systems used to support production and workforce administration.
  • Ability to work flexible hours and support off-shift, weekend, or business-critical operations as needed.
Responsibilities
  • Oversees daily shift operations to ensure safe, compliant, and efficient production.
  • This role leads and coaches manufacturing employees, sets team objectives, addresses operational challenges, and ensures adherence to cGMP, quality, documentation, data integrity, EH&S, and regulatory requirements.
  • The Supervisor partners with cross-functional teams, supports training and performance management, contributes to workforce planning and process improvements, and fosters a collaborative, productive, and compliant work environment.
  • Shift Schedule: This position follows a weekend-focused schedule consisting of two 12-hour overnight shifts (Friday 10:00 PM–Saturday 10:00 AM and Saturday 10:00 PM–Sunday 10:00 AM), in addition to two 8-hour weekday shifts. Weekday schedules are determined based on operational requirements and may offer flexibility in assigned days and hours.
  • Monitor day-to-day operations in the manufacturing area and address routine operational issues, escalating to management or support functions as needed.
  • Maintain a visible floor presence to monitor work practices, reinforce standards, support troubleshooting, and promote safe and compliant behaviors.
  • Coordinate staffing, work assignments, shift handoffs, and team communication to ensure continuity of operations and effective execution across shifts.
  • Partner with Quality, Engineering, Maintenance, Labs, EHS, IT, and other support groups to resolve operational issues and support area performance.
  • Ensure employees are trained, qualified, and current on required job, safety, and compliance training before performing assigned work.
  • Conduct regular coaching, performance feedback, and performance evaluations, and support employee development planning.
  • Support workforce administration activities including timekeeping, attendance monitoring, overtime tracking, onboarding support, and maintenance of employee information in company systems.
  • Participate in continuous improvement initiatives and use problem-solving tools to improve safety, quality, efficiency, and team performance.
  • Represent the assigned area in meetings, audits, inspections, and investigations, providing accurate information and follow-up support as needed.
  • Use manufacturing and business systems to support production tracking, documentation, training compliance, and routine operational oversight.

Takeda is a global biopharmaceutical company focused on discovering and delivering medicines and vaccines to improve patient health. It relies on extensive research and development to create new molecular entities (NMEs) and bring them to market, aiming for up to 15 product launches through FY2024 from a pipeline of 11 NMEs. Revenue comes mainly from selling pharmaceutical products, supported by about 41,000 third-party suppliers worldwide. The company differentiates itself through a deep history (over 240 years), a broad portfolio of global brands, and a patient-centric approach that places patients’ needs at the center of its operations while pursuing environmental sustainability. Takeda’s goal is to advance health globally by turning scientific innovations into accessible therapies, maintaining long-term growth through steady product innovation and responsible operations.

Company Size

10,001+

Company Stage

IPO

Headquarters

Tokyo, Japan

Founded

1781

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Simplify Jobs

Simplify's Take

What believers are saying

  • August 2026 FDA approval for MIMRYLO unlocks near-term U.S. oncology revenue.
  • Takeda expects ORZEYFUL U.S. launch by November 2026, pending DEA scheduling.
  • Q1 FY2026 new launches grew 22.6%, offsetting mature-brand declines and supporting guidance.

What critics are saying

  • May 18, 2026 AMITIZA verdict exposed Takeda to $2.6 billion treble-damage risk.
  • Takeda plans 4,500 FY2026 cuts, signaling launch execution pressure and organizational churn.
  • Patent erosion crushed VYVANSE sales 60.7% at constant currency in Q1 FY2026.

What makes Takeda unique

  • ORZEYFUL became the first orexin agonist approved for narcolepsy type 1 in 2026.
  • MIMRYLO offers first-in-class hepcidin mimetic therapy for polycythemia vera after FDA approval.
  • Takeda pairs global scale with Japanese discovery, including Shonan-led neurology innovation.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

401(k) Retirement Plan

401(k) Company Match

Paid Vacation

Paid Sick Leave

Wellness Program

Tuition Reimbursement

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

0%

2 year growth

0%
Associated Press
Sep 9th, 2026
Trialbee unveils AI-powered patient screening chatbot at DPHARM 2026

Trialbee, a patient recruitment platform provider, will present at DPHARM 2026 in Boston on 15-16 September. The Swedish-American company will unveil AI-powered patient screening in its Honey Platform, enabling conversational AI chatbots to conduct initial candidate assessments whilst giving patients the option to speak with recruitment specialists. Trialbee will present jointly with pharmaceutical company Takeda on integrating their respective platforms to build research-ready patient communities that extend beyond single trials. The company will also participate in a panel discussing AI applications at clinical trial sites. The Honey Platform has added several AI features this year, including candidate summaries, duplicate detection, and recruitment data analysis. Trialbee supports over 6,000 research sites across 50 countries and reports a 91% repeat business rate with biopharmaceutical companies.

Associated Press
Sep 9th, 2026
Onco360 selected as specialty pharmacy partner for rare blood cancer drug MIMRYLO

Onco360, a US independent speciality pharmacy, has been selected by Takeda Pharmaceuticals as an ultra-narrow limited distribution partner for MIMRYLO (rusfertide). The treatment is indicated for erythrocytosis in adults with polycythemia vera. MIMRYLO is a mimetic of the endogenous hormone hepcidin that blocks the iron transporter ferroportin. This inhibition reduces iron availability for red blood cell production, resulting in lower hematocrit levels. The drug's approval was based on the phase 3 VERIFY study, a global, randomised, open-label clinical trial. The primary endpoint measured the proportion of patients achieving response during weeks 20-32, defined as the absence of phlebotomy eligibility. The most common adverse reactions were injection site reactions at 56% and anaemia at 16%.

Yahoo Finance
Aug 31st, 2026
Takeda wins FDA approval for first-in-class blood cancer drug, triggering $275M payment to Protagonist

The FDA approved Takeda Pharmaceutical's MIMRYLO (rusfertide) for polycythemia vera, a blood cancer causing red blood cell overproduction. The first-in-class drug functions as a hepcidin mimetic, regulating iron distribution to control hematocrit levels and prevent life-threatening complications like strokes and pulmonary embolisms. Approval was based on the Phase 3 VERIFY study involving 293 patients. Those receiving MIMRYLO alongside standard care achieved superior hematocrit control, reduced phlebotomy needs, and improved fatigue compared to placebo. Takeda commercialises MIMRYLO under a 2024 agreement with Protagonist Therapeutics, which discovered the drug. The approval triggers $275 million in payments to Protagonist—a $200 million opt-out fee plus $75 million milestone. Protagonist remains eligible for up to $875 million in additional milestones and tiered royalties of 14% to 29% on worldwide net sales.

Associated Press
Aug 28th, 2026
US FDA approves Takeda's Mimrylo for polycythemia vera treatment

Takeda has received US FDA approval for MIMRYLO (rusfertide), a first-in-class treatment for erythrocytosis in adults with polycythemia vera (PV), a blood cancer. The drug is a hepcidin mimetic that regulates iron distribution and red blood cell overproduction to control hematocrit levels. The approval was supported by the Phase 3 VERIFY study involving 293 PV patients. Results showed MIMRYLO plus standard care demonstrated higher response rates than placebo, including better hematocrit control, reduced phlebotomy needs, and improved fatigue scores. PV affects approximately 90,000 people in the US. An estimated 78% of patients experience uncontrolled hematocrit with current standard care. The most common adverse events were injection site reactions and anaemia. MIMRYLO is administered once weekly via subcutaneous injection. Takeda is working with regulators outside the US for potential global availability.

Associated Press
Aug 24th, 2026
Japan approves Orzeyful as first medicine targeting narcolepsy type 1's underlying cause

Takeda announced Japan's Ministry of Health, Labour and Welfare has approved ORZEYFUL (oveporexton) for treating narcolepsy type 1 in adults. The oral medication is the first to address the underlying orexin deficiency causing the disease, rather than just managing individual symptoms. Narcolepsy type 1 is a chronic neurological condition characterised by excessive daytime sleepiness, cataplexy, disrupted sleep, and other symptoms that significantly impact patients' daily lives. Diagnostic delays average more than 10 years. The approval follows global Phase 3 trials showing statistically significant improvements across the full range of symptoms. Common side effects included insomnia, urinary urgency and frequency, and excessive saliva. ORZEYFUL is also approved in China and the United States. Takeda developed the first-in-class orexin receptor 2 agonist in its Japanese laboratories and plans to launch the treatment quickly.