Full-Time

Senior Scientist

Analytical Development and Quality Control

Posted on 8/12/2024

Altos Labs

Altos Labs

501-1,000 employees

Biotechnology focused on cell rejuvenation research

Biotechnology
Healthcare

Compensation Overview

$165k - $277.2kAnnually

Senior

Oakland, CA, USA

Salary range mentioned for Redwood City, CA.

Category
Bioinformatics
Biology Lab & Research
Biology & Biotech
Requirements
  • Ph.D. in analytical sciences or biological sciences.
  • Minimum 6+ years of analytical development and QC experience in biotech/pharmaceutical industry.
  • Highly experienced in developing and implementing titer assays for biologics and/or AAV gene therapy products including DS/DP and residuals, and QC testing for release, in-process and stability.
  • Proficient in phase appropriate qualification/validation requirements, cGMP’s and pharmaceutical industry procedures and regulations.
  • Strong problem-solving skills with the ability to interpret complex data sets.
  • Experienced in achieving CMC deliverables for QC assays outsourced to CROs.
  • Knowledge of regulatory requirements and quality standards related to release of AAV DS/DP.
  • Ability to work in a dynamic environment, with a willingness to learn new skills and adapt to shifting priorities and tasks.
  • Excellent communication skills. Proven capability to collaborate effectively in a diverse, global, cross-functional structure and commit to diversity, equity, and belonging.
Responsibilities
  • Lead internal and/or external development of phase-appropriate capsid (Cp) titer, residuals as well as purity and impurity assays, with an initial focus on AAV gene therapy programs.
  • Design and develop assays for Cp titer by ELISA, Surface Plasma Resonance and/or SEC-HPLC, Purity assay by CE, Full/Empty capsid ratio by AEX and/or SEC-HPLC and/or charge detection mass spectrometry (CDMS).
  • Lead the timely transfer of the developed assay to external vendor/s as needed, and manage external assay development/qualification for release and stability testing at the CRO.
  • Serve as a technical expert in CMC-appropriate analytical assays for Vg and Cp titer, Full/Empty ratio and residuals, establishment of product specifications and OOS/OOT investigations.
  • Author, review, and/or approve Standard Operating Procedures, development reports, qualification protocols and reports, specifications, regulatory filing and/or other controlled documents.
  • Collaborate cross-functionally with process development, quality control, QA, Institutes of Science, development sciences, clinical, regulatory, program management, legal and finance.
  • Recruit and provide direction and training to development associates as the team expands.
  • Stay abreast of industry trends, emerging technologies, and regulatory guidelines to contribute to the continuous improvement of analytical methods, quality control and specifications.
  • Actively contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion.

Altos Labs specializes in biotechnology with a focus on cell rejuvenation, aiming to restore cell health and resilience to reverse diseases and injuries. Their approach involves cellular rejuvenation programming, which enhances cells' ability to resist stressors that can lead to illness. Unlike competitors, Altos Labs emphasizes research and collaboration with other institutions to develop effective treatments. The company's goal is to improve patients' quality of life through breakthrough therapies.

Company Stage

Seed

Total Funding

$3.2B

Headquarters

Los Altos, California

Founded

2021

Growth & Insights
Headcount

6 month growth

0%

1 year growth

0%

2 year growth

4%
Simplify Jobs

Simplify's Take

What believers are saying

  • Significant funding of $270 million supports Altos Labs' research and development efforts.
  • The economic potential of increased life expectancy is recognized as a major opportunity.
  • Collaborations with tech industry veterans accelerate innovation and commercialization.

What critics are saying

  • Ethical concerns about lifespan extension may lead to regulatory challenges.
  • Intensifying competition in the biotechnology sector could dilute market share.
  • High expectations from financial backers may pressure the company to deliver quickly.

What makes Altos Labs unique

  • Altos Labs focuses on cellular rejuvenation to reverse diseases and improve health.
  • The company integrates computational biology and CRISPR technology for innovative solutions.
  • Altos Labs collaborates with leading scientists, including Nobel laureate Jennifer Doudna.

Help us improve and share your feedback! Did you find this helpful?

INACTIVE