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Full-Time

Senior Scientist

Analytical Development and Quality Control

Confirmed live in the last 24 hours

Altos Labs

Altos Labs

201-500 employees

Biotechnology focused on cell rejuvenation research

Biotechnology
Healthcare

Compensation Overview

$165k - $277.2kAnnually

Senior, Expert

Oakland, CA, USA

Category
Computational Biology
Genomics
Biology Lab & Research
Biology & Biotech
Requirements
  • Ph.D. in analytical sciences or biological sciences. Minimum 6+ years of analytical development and QC experience in biotech/pharmaceutical industry.
  • Highly experienced in developing and implementing titer assays for AAV gene therapy products including DS/DP and residuals, and QC testing for release, in-process and stability.
  • Proficient in phase appropriate qualification/validation requirements, cGMP’s and pharmaceutical industry procedures and regulations.
  • Strong problem-solving skills with the ability to interpret complex data sets.
  • Experienced in achieving CMC deliverables for QC assays outsourced to CROs.
  • Knowledge of regulatory requirements and quality standards related to release of AAV DS/DP.
  • Ability to work in a dynamic environment, with a willingness to learn new skills and adapt to shifting priorities and tasks.
  • Excellent communication skills. Proven capability to collaborate effectively in a diverse, global, cross-functional structure and commit to diversity, equity, and belonging.
Responsibilities
  • Lead internal and/or external development of phase-appropriate vector genome (Vg), capsid (Cp) titer, residuals as well as purity and impurity assays, with an initial focus on AAV gene therapy programs.
  • Design and develop ddPCR-based assays for Vg titer, host cell DNA and plasmid DNA.
  • Design and develop assays for Cp titer by ELISA, Surface Plasma Resonance and/or SEC-HPLC, Purity assay by CE, Full/Empty capsid ratio by AEX and/or SEC-HPLC and/or charge detection mass spectrometry (CDMS).
  • Lead the timely transfer of the developed assay to external vendor/s as needed, and manage external assay development/qualification for release and stability testing at the CRO.
  • Serve as a technical expert in CMC-appropriate analytical assays for Vg and Cp titer, Full/Empty ratio and residuals, establishment of product specifications and OOS/OOT investigations.
  • Author, review, and/or approve Standard Operating Procedures, development reports, qualification protocols and reports, specifications, regulatory filing and/or other controlled documents.
  • Collaborate cross-functionally with process development, quality control, QA, Institutes of Science, development sciences, clinical, regulatory, program management, legal and finance.
  • Recruit and provide direction and training to development associates as the team expands.
  • Stay abreast of industry trends, emerging technologies, and regulatory guidelines to contribute to the continuous improvement of analytical methods, quality control and specifications.
  • Actively contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion.

Altos Labs specializes in biotechnology with a focus on cell rejuvenation, aiming to restore cell health and resilience to reverse diseases and injuries. Their approach involves cellular rejuvenation programming, which enhances cells' ability to resist stressors that can lead to illness. Unlike competitors, Altos Labs emphasizes collaboration with research institutions and healthcare providers to advance their scientific research. The company's goal is to improve patients' quality of life by developing effective treatments through cell rejuvenation.

Company Stage

Series A

Total Funding

$6.3B

Headquarters

Los Altos, California

Founded

2021

Growth & Insights
Headcount

6 month growth

2%

1 year growth

8%

2 year growth

81%
Simplify Jobs

Simplify's Take

What believers are saying

  • Altos Labs' pioneering work in cell rejuvenation could lead to revolutionary treatments that significantly improve quality of life and longevity.
  • The company's strong financial backing and high-profile leadership offer stability and growth potential for employees.
  • Collaborations with leading research institutions and healthcare providers can open up numerous opportunities for professional development and innovation.

What critics are saying

  • The highly experimental nature of cellular rejuvenation means that successful commercialization is uncertain and could take years.
  • High expectations from investors and the public could lead to pressure and stress for employees.

What makes Altos Labs unique

  • Altos Labs focuses on cellular rejuvenation, a niche yet groundbreaking area in biotechnology, setting it apart from traditional biotech firms.
  • The involvement of Nobel laureates like Jennifer Doudna in their board of directors adds unparalleled scientific credibility and expertise.
  • Significant funding from high-profile investors like Jeff Bezos provides a robust financial foundation for extensive R&D.