Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a Scientist to join our discovery DMPK group in the Chemistry Department. The successful candidate will play a critical role in understanding the ADME of Arrowhead’s TRIM platforms targeting new cell types.

Responsibilities:

Draft ADME study requests
Perform cell type separation, enrichment and depletion as needed
Perform LC-HRMS, LC-UV or qPCR based quantitation
Interpret ADME results to facilitate drug delivery
Act as discovery DMPK lead and present data in cross-functional meetings
Document experimental procedure and results accurately
Execute all assays in a timely manner to meet deadlines
Be able to work in a highly dynamic and fast-moving environment; meet project goal within deadline

Requirements:

PhD in pharmacology or biological sciences
Hands-on experience with one of the quantitation method listed above from biological matrices
Hands-on experience with cell separation, enrichment or depletion
Demonstrated innovation, creativity and resilience in problem solving
Excellent oral and written communication skills and collaborative personality
Highly self-motivated with a can-do attitude

Preferred:

Extensive experience in cell separation, enrichment and depletion
Demonstrated practical understanding of pharmacokinetics and pharmacodynamics

Wisconsin pay range

$100,000—$130,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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Sr. Scientist

Discovery DMPK

Arrowhead Pharmaceuticals

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