Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy. 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking CAR-T Process Development (multiple levels) as part of the R&D team based in Nanjing, China. 

Key Responsibilities  

• Lead a discovery research team developing innovative ways to manufacture cell products for clinical trials.
• Subject matter expert in CAR-T cell process development and manufacturing.
• Execute research timelines to meet program and corporate objectives.
• Design, execute, and interpret process development study data to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.
• Write and review protocols, SOPs, technical reports, regulatory documents, and memos to summarize experiments and investigations.
• Partner with internal cross-functional team members to facilitate technical assessment, technical transfer, and IND filing.
• Closely mentor scientists to further develop talents within the group.
• Other duties will be assigned, as necessary.

Requirements

• Ph.D. in Cell Biology, Immunology, Genetic Engineering , or related discipline.
• Minimum of 6+ years relevant pharmaceutical industry/academic experience post-graduation.
• Extensive hands-on experience with CRSIPR- genome engineering in multiple cell types.
• Independently design constructs and sgRNA for KO/KI through non-viral gene transfer technologies (EP, LNP) or viral transfer technologies (LVV, RVV, VLP).
• Profound skills in analytical methods including but not limited to flow cytometry, real-time PCR, off-target evaluation, NGS, ddPCR.
• Extensive experience in CAR-T, CAR-γδT, or CAR-NK cell immunotherapies, including cell culture, immune cell activation, expansion, viral transduction or /and non-viral gene transfer, in vitro & in vivo characterization.
• Team management experience is preferred.
• Excellent communication skills both in English and Chinese, detail-oriented organization skills, and team collaboration skills.
• Strong ability to analyze data, report data, present findings to management is required.
• Ability to manage priorities and make decisions in a fast-paced environment to make sure deliverables are achieved in a timely fashion.
• A strong track record of scientific accomplishments, including first-author publications, patent applications, and/or presentations at major national meetings, is required.
• Occasional domestic or international travel required.

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.