Full-Time

Senior Principal Scientist

Computational Chemistry, ADC Chemistry

Updated on 1/8/2025

Pfizer

Pfizer

10,001+ employees

Develops and manufactures vaccines and medicines

Social Impact
Biotechnology
Healthcare

Compensation Overview

$117.3k - $201.4kAnnually

+ Bonus

Senior

No H1B Sponsorship

Bothell, WA, USA

Relocation support available.

Category
Computational Biology
Biology Lab & Research
Biology & Biotech
Required Skills
Linux/Unix
Requirements
  • PhD in computational chemistry or a related discipline
  • 5+ years of experience in the Biopharmaceutical Industry
  • Leading-edge knowledge of computational chemistry principles
  • Strong Linux and programming skills
  • Strong publication record
  • Strong working knowledge of related disciplines in drug discovery such as medicinal chemistry, structural biology, pharmacology and biophysics, in vivo biology, drug metabolism and drug safety
Responsibilities
  • Structure Based Drug Design(SBDD) and conformational analysis to optimize potency and physico-chemical properties of payloads and payloads-linkers
  • Impact drug discovery projects by identifying the highest impact computational chemistry approaches for specific projects
  • Developing and delivering timely, high-quality computational solutions
  • Participate on multiple interdisciplinary project teams and play a key role in defining project strategies
  • Analyze potential payload targets to assess their druggability and determine the most promising approaches
  • Design payloads and linkers suitable for ADCs in collaboration with design/synthesis chemists
  • Apply molecular modeling and dynamics, AI and homology modeling and related techniques to understand biological targets and the mechanisms of payloads
  • Use both physics-based and AI/ML methods to impact compound design and screening
  • Bring new computational approaches from within global Computational Chemistry in Pfizer and the literature to speed ADC discovery
  • Define, implement, and influence project design strategy to deliver projects to key decision points
  • Influence science at both departmental and external level
  • Effective mentor for colleagues in department

Pfizer focuses on creating and producing healthcare products, particularly medicines and vaccines. The company conducts extensive research and development to discover new treatments, which are then manufactured and sold globally. Pfizer's products include vaccines, cancer treatments, and other specialized medications. A key aspect of Pfizer's operations is its partnership with BioNTech to develop a vaccine for COVID-19, showcasing its role in addressing public health challenges. Unlike many competitors, Pfizer emphasizes not only the development of new drugs but also the distribution of vaccines to underserved communities. The company's goal is to enhance public health by expanding its range of effective treatments and ensuring access to its products worldwide.

Company Stage

IPO

Total Funding

$3.8B

Headquarters

New York City, New York

Founded

1849

Simplify Jobs

Simplify's Take

What believers are saying

  • Strategic partnerships accelerate novel cancer therapies development, especially in multiple myeloma.
  • Increased investment in AI enhances Pfizer's innovation pipeline and R&D efficiency.
  • Pfizer's financing in immunotherapies and fibrosis treatments expands its product portfolio.

What critics are saying

  • Slowdown in COVID-19 vaccine demand has led to a slump in Pfizer's shares.
  • Activist investor pressure may lead to strategic changes misaligned with long-term goals.
  • Resource diversion from core operations due to multiple investment ventures.

What makes Pfizer unique

  • Pfizer's partnership with BioNTech led to a highly effective COVID-19 vaccine.
  • The company focuses on innovative medicines and vaccines for global distribution.
  • Pfizer invests in AI-driven drug discovery to enhance R&D efficiency.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

401(k) Retirement Plan

401(k) Company Match

Paid Vacation

Paid Sick Leave

Paid Holidays

Hybrid Work Options

Relocation Assistance