Full-Time

Senior Principal Scientist

Small Molecule Computational Chemist

Posted on 12/20/2024

Pfizer

Pfizer

10,001+ employees

Develops and manufactures vaccines and medicines

Social Impact
Biotechnology
Healthcare

Compensation Overview

$120.8k - $201.4kAnnually

+ Bonus

Senior

No H1B Sponsorship

Bothell, WA, USA

Relocation support available.

Category
Computational Biology
Biology Lab & Research
Biology & Biotech
Required Skills
Linux/Unix

You match the following Pfizer's candidate preferences

Employers are more likely to interview you if you match these preferences:

Degree
Experience
Requirements
  • PhD in computational chemistry or a related discipline
  • 5+ years of experience in the Biopharmaceutical Industry
  • Leading-edge knowledge of computational chemistry principles
  • Strong Linux and programming skills
  • Ability to work in a collaborative environment
  • Strong working knowledge of related disciplines in drug discovery such as medicinal chemistry, structural biology, pharmacology and biophysics, in vivo biology, drug metabolism and drug safety
Responsibilities
  • Structure Based Drug Design (SBDD) and conformational analysis to optimize potency and physico-chemical properties of payloads and payloads-linkers
  • Impact drug discovery projects by identifying the highest impact computational chemistry approaches for specific projects
  • Develop and deliver timely, high-quality computational solutions
  • Participate on multiple interdisciplinary project teams and play a key role in defining project strategies
  • Analyze potential payload targets to assess their druggability and determine the most promising approaches
  • Design payloads and linkers suitable for ADCs in collaboration with design/synthesis chemists
  • Apply molecular modeling and dynamics, AI and homology modeling and related techniques to understand biological targets and the mechanisms of payloads
  • Use both physics-based and AI/ML methods to impact compound design and screening
  • Bring new computational approaches from within global Computational Chemistry in Pfizer and the literature to speed ADC discovery
  • Define, implement, and influence project design strategy to deliver projects to key decision points
  • Influence science at both departmental and external level
  • Act as an effective mentor for colleagues in the department
Desired Qualifications
  • Leading-edge knowledge of computational chemistry concepts and techniques such as structure-based and ligand-based drug design, protein-ligand interactions, docking and scoring, virtual screening, cheminformatics, QSAR and predictive modeling, AI/ML-based protein modeling and homology modeling, molecular dynamics simulations, free energy perturbation methodologies, AI/ML and generative chemistry for drug design, and application of quantum chemical calculations to drug discovery
  • Familiarity with standard computational chemistry software such as the Schrodinger suite, CCG MOE, Pipeline Pilot, Gaussian, OpenEye
  • Programming and scripting skills (e.g. Python, Linux workflows); experience developing workflows using scientific, numeric, and chemistry libraries such as the OpenEye toolkits and simulation packages such as OpenMM, AMBER, GROMACS, and CHARMM
  • Strong working knowledge of related disciplines in drug discovery such as medicinal chemistry, structural biology, pharmacology and biophysics, in vivo biology, drug metabolism and drug safety
  • Demonstrated breadth of diverse leadership experiences and capabilities including the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact

Pfizer focuses on creating and producing healthcare products, particularly medicines and vaccines. The company conducts extensive research and development to discover new treatments, which are then manufactured and sold globally. Pfizer's products include vaccines, cancer treatments, and other specialized medications. A key aspect of Pfizer's operations is its partnership with BioNTech to develop a vaccine for COVID-19, showcasing its role in addressing public health challenges. Unlike many competitors, Pfizer emphasizes not only the development of new drugs but also the distribution of vaccines to underserved communities. The company's goal is to enhance public health by expanding its range of effective treatments and ensuring access to its products worldwide.

Company Stage

IPO

Total Funding

$3.8B

Headquarters

New York City, New York

Founded

1849

Simplify Jobs

Simplify's Take

What believers are saying

  • Starboard Value's $1 billion stake may drive strategic changes and increase shareholder value.
  • Pfizer's investment in fibrosis treatments expands its therapeutic areas.
  • Involvement in protein modification research diversifies Pfizer's treatment offerings.

What critics are saying

  • Slowdown in COVID-19 vaccine demand impacts Pfizer's revenue streams.
  • Activist investor Starboard Value may influence Pfizer's strategic decisions.
  • Emerging biotech companies pose a threat to Pfizer's market share in immunotherapy.

What makes Pfizer unique

  • Pfizer's partnership with BioNTech led to a highly effective COVID-19 vaccine.
  • Pfizer invests in AI disease models, enhancing predictive insights for drug development.
  • Pfizer's oncology portfolio is strengthened by investments in TCR-based immunotherapies.

Help us improve and share your feedback! Did you find this helpful?

Benefits

Health Insurance

Dental Insurance

Vision Insurance

401(k) Retirement Plan

401(k) Company Match

Paid Vacation

Paid Sick Leave

Paid Holidays

Hybrid Work Options

Relocation Assistance

INACTIVE