ADME Scientist

Job Description

Job Focus: A contractor position is available for a skilled scientist to join in Pfizer’s Pharmacokinetics Dynamics and Metabolism New Biological Entities (PDM-NBE) ADME group to address diverse and complex scientific ADME issues pertaining to protein biotherapeutics. This lab based role involves the scientific and technical support of in vitro and in vivo pre-clinical studies designed to understand mechanistic ADME characteristics of biotherapeutics which will support the development of predictive pharmacological tools. The candidate will participate in all phases of laboratory operations relating to biotherapeutic PK/tissue distribution/tissue catabolism study execution, sample preparation, and data analysis. We are looking for a scientist passionate about learning and able to quickly apply new skills to the project needs.

Responsibilities: 

• Independent sample preparation and analysis for in vitro and in vivo radiolabeled PK/drug tissue distribution/tissue catabolism studies using appropriate method of analysis (primarily gamma counter detection)

• Handling of biological samples, preclinical serum and tissues

• Occasional use of cell culture, SDS-PAGE, or binding assays may be required

• Perform under minimal supervision; initiative in method development is expected

• Independent daily operation, calibration, maintenance, and trouble shooting of instrumentation

• Summarization and documentation of experiments

Qualifications, Technical Skills and Experience: 

• BS/MS level education in Biochemistry, Biology, Pharmacology or closely related fields required

• Industry experience in biopharma preferred

• Experience using radioactive materials (125I, 111In) is strongly preferred

• Experience with SDS-PAGE, binding assays, or cell culture is a plus

• Knowledge of IACUC, animal use protocols, PKPD study design and concepts is a plus

• High level of initiative in performing experiments, multi-tasking and troubleshooting

• Fast learner and be able to master running/maintaining instruments after a short period of training

• Strong interpersonal skills, communication (verbal and written)

• Works well both independently and as part of a team. Collaborative skills and effective partnering skills in a matrix-environment is necessary

• Strong data organization and analysis skills

Qualifications

Additional Information

Best Regards,

Anuj Mehta

973-967-3402