Engineer II
Polysaccharide Downstream Process Development
Confirmed live in the last 24 hours

201-500 employees

Develops broad-spectrum vaccines for bacterial diseases
Company Overview
Vaxcyte is a pioneering vaccine company that is redefining the production of complex immunizations through advanced synthetic techniques, including the XpressCFᵀᴹ cell-free protein synthesis platform, which is designed to expedite the creation and delivery of high-fidelity vaccines. The company's lead candidate, VAX-24, a broad-spectrum pneumococcal conjugate vaccine, has been granted FDA Breakthrough Therapy designation, demonstrating its potential in preventing invasive pneumococcal disease. With a culture focused on eradicating or treating invasive bacterial infections, Vaxcyte is leading the industry in developing vaccines with an expanded breadth of coverage, including candidates designed to prevent Group A Strep infections and slow the progression of periodontal disease.

Company Stage


Total Funding





San Carlos, California

Growth & Insights

6 month growth


1 year growth


2 year growth

San Carlos, CA, USA
Experience Level
Desired Skills
  • BS in Chemical/Bio Engineering, Biochemistry, or a related discipline, with 6+ years of industry experience; MS with 3+ years of industry experience
  • Hands-on experience with high-throughput screening techniques and liquid-handling robotic programming with Tecan Fluent or similar instrument
  • Practical experience with and theoretical knowledge of traditional processing unit operations including TFF, depth filtration, continuous centrifugation, and chromatography
  • Familiarity with DoE (Design of Experiments) principles; practical experience with DoE software
  • Demonstrated proficiency with engineering principles involved in scaling processes from lab to pilot scale
  • Proficient with computer programs such as Microsoft Excel, Word, PowerPoint, Visio and JMP
  • Experience with process modelling software a plus
  • Working knowledge of the requirements of GMPs
  • Ability to travel internationally to a CMO as some international travel may be required
  • Demonstrated success working in a cross-functional team environment on multiple projects; ability to work effectively as a member of a team to deliver results
  • Strong interpersonal skills, with excellent written and verbal communication skills
  • All Vaxcyte employees require vaccination against COVID-19
  • Operate and maintain instrumentation for polysaccharide purification including automated liquid-handling robot (Tecan Fluent), TFF systems, Akta chromatography skids, automated filtration units and centrifuges
  • Perform analysis and interpret results for polysaccharide and impurity assays (Anthrone, Lowry, SEC-MALS, HPAEC-PAD etc…)
  • Assists in design and execution of downstream process characterization studies
  • Work with team to develop purification strategies for pipeline projects
  • Keep accurate and current records of development experiments and/or project related activities in laboratory notebooks or electronic notebook
  • Review executed protocols and batch records
  • Present/communicate data to polysaccharide team
  • Contribute to technical discussions within the polysaccharide team
  • Writes, reviews, and approves R&D protocols, batch records, and reports in support of process development
  • Works within a team environment and provides support as necessary to further the team's initiatives
Desired Qualifications
  • Late-stage process characterization experience is a plus