Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on delivering oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Kymera is also progressing degrader oncology programs that target undrugged or poorly drugged proteins to create new ways to fight cancer. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll contribute:

You will seamlessly partner with all line functions represented on the project teams and will be accountable to set DMPK strategy and drive execution to advance projects from early discovery through preclinical development. Your deep expertise in PK/ADME strategies and tactics in small molecule drug discovery and preclinical development is foundational, and hands-on experiences in PK and PK/PD modeling will serve you well. You will thrive in a collaborative, past-paced, interdisciplinary team environment.

• Represent DMPK function as core project team member. Accountability for all DMPK studies. Planning, stewardship, analysis, and integration of all in In Vitro and In Vivo ADME, PK, and PK/PD efforts in support of discovery and preclinical development programs.
• Conduct basic PK and PK/PD modeling, provide predicted human PK and efficacious dose projections and DDI risk assessment.
• Design and implementation of DMPK strategies for NCE optimization and characterization in collaboration with project and functional stakeholders.
• Outstanding, proactive collaboration with all team functions (Pharmacology, Toxicology, Pharm. Sci., Chemistry, Translational Medicine) to secure effective advancement of Kymera’s projects and portfolio. Influence wider project strategy and team decision making.
• Manage interactions with CROs to ensure high quality and on-time execution of DMPK studies.
• Author and review relevant sections of regulatory documents.
• Contribute to Kymera’s internal and external presentation/publication strategy.

What skills and experience you’ll bring:

• MSc or PhD in Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related disciplines.
• 15+ years (with MSc) or 5 - 10 years (with PhD) of relevant experience in the Pharmaceutical/Biotech industry.
• Prior experience as a core DMPK project team representative on a multifunctional team is required.
• In-depth understanding and strategic application of all PK/ADME assays, methods and models. Ability to distill critical information, develop structure-property relationships, clear strategic guidance in support of effective multi-parametric NCE optimization.
• Strong understanding of DMPK, PK/PD modeling, human PK, efficacious dose, and DDI prediction strategies, incl. all required input from adjacent functions.
• Expertise in managing CROs, robust knowledge of relevant regulatory guidances.
• Proficiency in Phoenix WinNonlin highly desired. Experiences with PBPK modeling are a plus.
• Passion for data driven analysis, and strongly developed business-of-science thinking.
• Excellence in analytical, organizational, and communication skills.
• Ability to thrive in a fast-paced, highly matrixed environment.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.