Full-Time

Senior Analytical Scientist I

Confirmed live in the last 24 hours

Arcellx

Arcellx

51-200 employees

Develops immunotherapies for cell therapy

Biotechnology
Healthcare

Senior, Expert

North Bethesda, MD, USA

Relocation assistance offered if required.

Category
Computational Biology
Biology Lab & Research
Biology & Biotech
Requirements
  • Bachelor’s degree with 10+ years of relevant work experience, or master’s degree with 8+ years’ experience, or PhD in relevant scientific discipline with 2+ years of postdoc or industry experience on protein or virus analysis.
  • Solid background knowledge and practical experience in biophysical techniques to characterize aggregates, subvisible and visible particles in proteins and/or viral vector products, such as flow imaging techniques, HIAC, NTA, SEC-MALS, FFF-MALS, DLS/SLS, etc.
  • Hands-on experience in thermodynamic analysis (DSC or DSF) to support formulation development or product characterization.
  • Prior experience in particle characterization and investigation in the late stage of CMC development is highly desired.
  • Experience in drafting and reviewing technical documents including analytical method SOPs, characterization protocols and reports.
  • Experience in applying Design of Experiment (DOE) and other appropriate statistics approaches during formulation development, analytical method development and robustness study is preferred.
  • Excellent collaborator with strong communication skills.
  • Proven self-starter with a high attention to scientific details and strong problem-solving skills.
Responsibilities
  • Serve as a biophysics SME (subject matter expert) in CMC activities including pre-formulation study, formulation development, in-process monitoring, product characterization, particle characterization and investigation.
  • Collaborate with a dynamic and engaging team of Arcellx scientists and CDMO partners to perform biophysical characterization and thermodynamic analysis on protein and lentivirus products.
  • Build strategies for protein or virus product quality analytical testing throughout the product lifecycle development.
  • Participate in designing long-term stability studies per regulatory guidelines and perform stability data trending analysis for drug substances, drug products and reference standards.
  • As a key contributor, design and coordinate accelerated and stressed stability study for manufacturability assessment, analytical method development, formulation development, CQA assessment and comparability study.
  • Author and review technical documents.
  • Perform and troubleshoot analytical assays to support CMC and some research activities.
  • Present scientific study design and findings at internal and external meetings.

Arcellx develops immunotherapies aimed at improving cell therapy for serious diseases. Their products work by harnessing the body's immune system to target and treat conditions that currently have limited treatment options. Unlike many competitors, Arcellx focuses specifically on proprietary immunotherapy products and has a business model that includes partnerships and licensing agreements to support their research and development efforts. The company's goal is to meet unmet medical needs by providing safe and effective treatment alternatives for patients.

Company Stage

IPO

Total Funding

$194.5M

Headquarters

Gaithersburg, Maryland

Founded

2014

Growth & Insights
Headcount

6 month growth

4%

1 year growth

0%

2 year growth

1%
Simplify Jobs

Simplify's Take

What believers are saying

  • Strategic partnership with Kite accelerates development and commercialization of therapies.
  • FDA support expedites approval process for Arcellx's innovative treatments.
  • Advancements in gene editing enhance precision of Arcellx's cell therapies.

What critics are saying

  • Competition from established CAR-T therapies like Abecma and Carvykti.
  • Dependency on Kite partnership could pose risks if dynamics change.
  • Phase 3 trial for anito-cel carries risk of not meeting endpoints.

What makes Arcellx unique

  • Arcellx's CART-ddBCMA has FDA Fast Track, Orphan Drug, and RMAT designations.
  • The ARC-SparX platform offers dosable and controllable CAR-T therapy options.
  • Anito-cel uses a novel D-Domain BCMA binder for enhanced antigen binding.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Unlimited Paid Time Off

Flexible Work Hours

401(k) Company Match

Fully-Paid Parental Leave

Tuition Reimbursement

Relocation Assistance