Position Title:
Postdoc Research Associate
Appointment Type:
Post Doc/Trainee
Job Description:
Summary of Duties and Responsibilities:
The postdoc will develop a generalizable QM/MM modeling framework for metalloenzymes containing bound metal cofactors, with a focus on the Ni(I)–F430 center of methyl-coenzyme M reductase (MCR). Using density functional theory (DFT), force-field parameterization, and hybrid QM/MM simulations, the postdoc will characterize bonding, non-bonding, and electronic interactions of metal centers under inhibitory conditions. This framework will be applied to predict how methane-blocking agents disrupt MCR catalysis in bovine rumen methanogenesis. The researcher will generate validated computational models that inform inhibitor design, ensuring mechanistic accuracy and transferability to other biologically relevant metalloenzymes.
Required Minimum Qualifications: PhD or Doctoral Degree
Preferred Qualifications:
Training in quantitative sciences (chemistry, physics, engineering)
Knowledge of scientific programming languages
Well-versed in numerical and analytical techniques
PhD in STEM field
Department Unit/Websites:
https://chowdhurylab.github.io/
Proposed Start Date:
October 13, 2025
Proposed End Date or Length of Term:
October 12, 2026
Number of Months Employed Per Year:
12 Month Work Period
Time Type:
Full time
Application Instructions:
To apply for this position, please click on “Apply” and complete the Employment Application. Please be prepared to enter or attach the following:
1) Resume/Curriculum Vitae
2) Letter of Application/Cover Letter
If you have questions regarding this application process, please email [email protected] or call 515-294-4800 or Toll Free: 1-877-477-7485.
Why Choose ISU?
Iowa State Postdocs enjoy comprehensive health and work-life benefits, including medical and dental; as well as:
• Retirement benefits including defined benefit and defined contribution plans
• Generous vacation, holiday, and sick time and leave plans
• Onsite childcare (Ames, Iowa)
• Flexible Spending Accounts
• Various voluntary benefits and discounts
• Employee Assistance Program
• Wellbeing Program
Original Posting Date:
October 6, 2025
Posting Close Date:
October 13, 2025
Job Requisition Number:
R17896
Lab & Research (2)