Principal Scientist

Job Description

Short Description:

We are seeking a Principal Scientist to manage genetic toxicology studies and to develop testing strategies that support drug candidate selection and regulatory submissions. This role involves the development, assessment, and implementation of new methods for genetic toxicology screening, as well as determining mechanisms of genetic toxicity and conducting risk assessments.

Position Description:

The Genetic Toxicology group within Nonclinical Drug Safety is looking for an experienced genetic toxicologist with expertise in risk assessment and the development of New Approach Methodologies (NAMs). The primary responsibilities include:

• Providing scientific leadership and supporting discovery project teams in genotoxicity screening and risk assessment strategies.
• Leading innovation in genetic toxicology through the development and implementation of new technologies, such as error-corrected next-generation sequencing (ecNGS) and in vitro tissue models.
• Establishing and validating in vivo and in vitro assays.
• Engaging with industry and regulatory bodies through external working groups.
• Staying current with the latest testing strategies and approaches.
• Influencing scientific direction through publications and presentations.

This position requires a laboratory component to establish new technologies and provide scientific oversight and mentorship to junior-level scientists.  The individual in this position will be expected to work collaboratively across many disciplines, thus effective written and verbal communication is critical.

Position Qualifications:

• PhD in Toxicology or a related field.
• 5+ years of post-doctoral experience in genetic toxicology.

Required Experience and Skills:

• Knowledge in genetic toxicology risk assessment and the application of investigative tools, including NAMs for genotoxicity and carcinogenicity risk assessment.
• Demonstrated scientific leadership in genetic toxicology.
• Experience managing and mentoring junior staff.
• Strong understanding of mechanistic genetic toxicology as it relates to risk assessment.
• Excellent oral and written communication skills.
• Proven collaboration and recognition within the field of genetic toxicology through scientific societies, working groups, or publications.
• Highly dedicated and motivated individual.

Preferred Experience and Skills:

• Experience applying mechanistic data from genetic toxicology for genotoxicity and carcinogenicity risk assessment.
• Advanced data management and visualization skills for high-content data analysis.
• Familiarity with ecNGS is a plus.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

11/26/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.